*Corresponding Author: Dr. Sarita Bhandari, Associate Professor, Department of Conservative Dentistry and Endodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai - 600077, India. Email: saritabhandari.sdc@saveetha.com
Background: Achillea millefolium (A. millefolium) is a perennial herb and has gained recognition for its therapeutic properties. It has properties of tissue regeneration, collagen synthesis, and anti-inflammatory effects. This study explores the phytochemical screening, antioxidant activity and anti cariogenic properties of A. millefolium, aiming to expand its applications in dentistry.
Materials and Methods: The study utilized methanolic extracts of shade-dried and coarsely ground A. millefolium leaves, prepared at room temperature. Phytochemical screening was conducted to identify key bioactive compounds. Antioxidant activity was evaluated using the DPPH radical scavenging assay. Anti cariogenic activity was assessed through the agar gel diffusion method, while biocompatibility was tested using the MTT assay.
Results: Phytochemical analysis of A. millefolium revealed the presence of flavonoids, phenolic acids, essential oils, alkaloids, tannins, terpenoids, coumarins, glycosides, and saponins. The extract demonstrated potent antioxidant, anti-inflammatory, anticariogenic and antibiofilm activities. Biocompatibility was confirmed through MTT assay and phase-contrast microscopy.
Conclusion: A. millefolium demonstrates significant potential as a therapeutic agent in dental applications. Its antioxidant, anti-inflammatory, anticariogenic and antibiofilm properties underline its efficacy.
Keywords: Achillea, Antioxidants, Dentin, Phytochemicals, Matrix Metalloproteinases.
How to cite this article: Khan HLA, Bhandari S, Uddin I. Anti-cariogenic potential and comprehensive phytochemical characterization of Achillea millefolium – an in vitro study. Int J Drug Deliv Technol. 2026;16(3s): 727-733; DOI: 10.25258/ijddt.16.3s.90
Source of support: Nil.
Conflict of interest: None