1* Department of Pharmaceutical Chemistry, Vinayaka Mission's College of Pharmacy, Vinayaka Missions Research Foundation – Deemed to be University (VMRFDU), Salem - 636308, Tamil Nadu, India (Corresponding Author). Email: sangeethakarthi2010@gmail.com
2 Department of Pharmaceutical Chemistry, Vinayaka Mission's College of Pharmacy, Vinayaka Missions Research Foundation – Deemed to be University (VMRFDU), Salem - 636308, Tamil Nadu, India. Email: naveenkumarsubash01@gmail.com
3 Department of Pharmaceutical Chemistry, Vinayaka Mission's College of Pharmacy, Vinayaka Missions Research Foundation – Deemed to be University (VMRFDU), Salem - 636308, Tamil Nadu, India. Email: pasup1077@gmail.com
4 Department of Pharmaceutical Chemistry, Vinayaka Mission's College of Pharmacy, Vinayaka Missions Research Foundation – Deemed to be University (VMRFDU), Salem - 636308, Tamil Nadu, India. Email: alexmpharm@gmail.com
5 Professor, Department of Pharmaceutical Chemistry, Vinayaka Mission's College of Pharmacy, Vinayaka Missions Research Foundation – Deemed to be University (VMRFDU), Salem - 636308, Tamil Nadu, India. Email: kumarvmcp@yahoo.co.in
The composition and assessment of Fexofenadine's fast-dissolving tablets (FDTs), a second-generation antihistamine frequently used to treat allergic diseases such as chronic urticaria and seasonal allergic rhinitis, are presented in this article. FDTs dissolve quickly in the oral cavity without the need for water, making them useful for individuals who have trouble swallowing pills. Despite its effectiveness, fexofenadine has a bitter taste, hence taste-masking ingredients must be included in the formulation. The study investigates how FDTs may improve bioavailability and lower first-pass metabolism by delivering a quicker beginning of action through absorption through the gastrointestinal system or oral mucosa. Microcrystalline cellulose (MCC), lactose, starch, acacia, and super disintegrants such as sodium starch glycolate (SSG) and croscarmellose sodium (CCS) were used as excipients in the formulation process. The tablets were prepared by direct compression. A number of criteria, such as the produced tablets' physical appearance, hardness, friability, disintegration time, and dissolving rate, were assessed. Studies on in-vitro dissolution showed that Fexofenadine was released quickly, indicating the possibility of quicker therapeutic effects. In order to improve the therapeutic experience for patients with allergies, this research offers important insights into the development of FDTs for antihistamine medications.
Keywords: Fexofenadine, antihistamines, taste-masking compounds, bioavailability, fast-dissolving tablets (FDTs), dissolution experiments
How to cite this article: Sangeetha S, Kumar SN, Pasupathi C, Alexandar S, Kumar M. Formulation Development and Optimization of Fast Dissolving Tablet for Fexofenadine and Its Evaluation. Int J Drug Deliv Technol. 2026;16(24s): 106-113. DOI: 10.25258/ijddt.16.24s.13
Source of support: Nil.
Conflict of interest: None