1,2,3,4,5 School Of Pharmacy, Krishna Institute Of Engineering & Technology (Kiet), Ghaziabad, Delhi-Ncr, Uttar Pradesh, India.
2 Orcid: https://orcid.org/0000-0002-6872-414X
6 School Of Medical And Allied Sciences, Gd Goenka University, Gurgaon, Haryana, India.
7 College Of Pharmacy, Sgt University, Budhera, Gurugram-Badli Road, Gurugram- 122505, Haryana, India.
Imeglimin is an innovative oral antidiabetic agent that represents a significant advancement in the treatment of type 2 diabetes mellitus (t2dm). Distinguished by its unique mitochondrial-targeting mechanism, imeglimin improves mitochondrial function to enhance insulin sensitivity, reduce hepatic glucose production, and preserve pancreatic β-cell function. Clinical trials have demonstrated its efficacy in lowering hba1c levels with a favorable safety profile and minimal adverse effects. In addition to its pharmacological benefits, various analytical methods, including high-performance liquid chromatography (hplc) and gas chromatography (gc), have been developed for the accurate quantification and pharmacokinetic evaluation of imeglimin, supporting its clinical application and therapeutic monitoring. While promising, potential drug-drug interactions, particularly with metformin and sulfonylureas, necessitate careful clinical consideration. Overall, imeglimin offers a novel and effective option for patients with t2dm inadequately controlled by existing therapies. Continued research is essential to elucidate its long-term benefits, optimize combination regimens, and refine analytical techniques to support personalized diabetes management.
Keywords: Imeglimin, Type 2 Diabetes Mellitus, Mitochondrial Dysfunction, Insulin Sensitivity, Analytical Method Development, Drug-Drug Interactions.
Source of support: None.
Conflict of interest: None.
How To Cite This Article: Ali Y, Kapoor G, Chaudhary R, Kumar S, Nagarajan K, Bhutani R, Kant R. Imeglimin In Type 2 Diabetes Mellitus: Pharmacological Advances, Clinical Efficacy, And Analytical Perspectives. Int J Drug Deliv Technol. 2026;16(4):451-465. Doi: 10.25258/ijddt.16.4.45