1 Sandip University, School Of Pharmaceutical Sciences, Mahirawani, Trimbak Road, Nashik.
Corresponding Author: Ms. Puja Vidhate, Email: poojavidhate7@gmail.com
The purpose of this study was to assess the effects of barleria sahyadrica extract on neuroprotection, anxiety, depression, and motor coordination in experimental animal models. Levetiracetam (10 mg/kg, standard) or barleria sahyadrica extract (100 and 300 mg/kg, p.o.) were administered to groups of albino rats. The elevated plus maze (epm), rotarod test, marble burying test, nestlet shredding test, and forced swim test (fst) were used to evaluate behaviour. The data were compared to a negative control and presented as mean ± sem. The extract from barleria sahyadrica showed notable neurobehavioral effects that were dose-dependent. Groups treated with extract exhibited more open-arm exploration in the epm, which is indicative of anxiolytic action. The rotarod test showed an improvement in motor performance. In the marble burying and nestlet shredding tests, obsessive-compulsive behavior was decreased, and the 300 mg/kg dosage had effects similar to those of levetiracetam. The extract demonstrated antidepressant-like effects in the fst by dramatically reducing immobility time. The 300 mg/kg dose continuously showed greater efficacy than the 100 mg/kg dose across all models. The results demonstrate that barleria sahyadrica has strong neuroprotective potential with anxiolytic, depressive, and anti-compulsive effects. These effects are probably caused by the phytoconstituents in the plant that have neuromodulatory and antioxidant qualities. These findings support its traditional medical application and point to its potential as a natural therapeutic option for the treatment of neuropsychiatric and neurodegenerative illnesses.
Keywords: Barleria Sahyadrica, Neuroprotective Activity, Antioxidant, Antianxiety.
How To Cite This Article: Vidhate P, Dudhe P. Neuroprotective Activity Of Botanical Study Of Barleria Sahydrica From The Ambai Region Of Maharashtra. Int J Drug Deliv Technol. 2026;16(4):473-480. Doi: 10.25258/ijddt.16.4.47