1* PhD Scholar, Department of Biochemistry, Maharishi Markandeshwar University Solan (HP)
2 Professor, Department of Biochemistry, Maharishi Markandeshwar University Solan (HP)
p>3 Professor, Department of Biochemistry, Maharishi Markandeshwar University Solan (HP)Objective: Individuals with family history of Type 2 diabetes mellitus (T2DM) are more disposed to developing the disease at a younger age due to collective genetic and environmental influences. Angiopoietin-like protein 6 (ANGPTL6), a liver derived hepatokine involved in regulation of glucose and lipid metabolism, is gaining attention for its possible role in insulin resistance (IR) and metabolic dysfunction. The early assessment of such biomarkers in high-risk individuals could contribute to early preventive strategies aimed at delaying or reducing the global burden of T2DM. Methods: This cross-sectional case-control study included 200 apparently healthy young adults aged 18–25 years. Among them, 100 participants had a positive family history of T2DM, while 100 age-matched participants without any family history of diabetes served as controls. Serum ANGPTL6 levels were estimated using ELISA. Results: Serum ANGPTL6 and HbA1c levels were significantly higher in participants with a family history of T2DM compared to controls respectivel. A strong positive correlation was observed between serum ANGPTL6 and HbA1c levels r=0.76, p, whereas a weak positive, non-significant correlation was found between serum ANGPTL6 and FBS levels (r=0.16, p=0.083). Conclusion: Elevated serum ANGPTL6 levels observed in young adults with a family history of T2DM. The significant positive relationship between ANGPTL6 and HbA1c suggests a possible association with long-term glycemic dysregulation, while FBS alone may not be able to detect early disturbances in glucose metabolism. These findings indicate that ANGPTL6 could have potential value as an early biomarker for identifying individuals at higher risk of developing T2DM
Keywords: Angiopoietin-like protein 6, β- cell dysfunction, T2DM, Young Adults, HbA1c, FBS, Insulin resistance.
How to cite this article: Thakur Priyanka, Walia Harpreet Kaur, CAN SERUM ANGIOPOIETIN-LIKE PROTEIN 6 BE AN EARLY INDICATOR OF TYPE 2 DIABETES MELLITUS IN YOUNG FIRST DEGREE RELATIVES OF TYPE 2 DIABETES MELLITUS t J Drug Deliv Technol. 2026;16(46s): 559-564. DOI: 10.25258/ijddt.16.46s.61
Source of support: Nil.
Conflict of interest: None.