Background: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a critical World Health Organization priority pathogen. Although blaKPC remains a major carbapenemase globally, the relative contribution of KPC compared with other mechanisms varies across regions and directly influences diagnostic strategies and use of newer β-lactam/β-lactamase inhibitor combinations. This study assessed the prevalence and clinical correlates of the blaKPC gene in K. pneumoniae isolates from a tertiary-care hospital with a high burden of carbapenem resistance.
Methods: In this cross-sectional laboratory-based study, 220 non-duplicate clinical K. pneumoniae isolates were collected over a 12-month period from blood, urine, pus, and other specimens. Demographic and ward data were retrieved from laboratory records. Antimicrobial susceptibility to carbapenems was determined using standard methods in accordance with contemporary guidelines. Carbapenemase production was screened using the Carba NP test. Detection of blaKPC was performed by polymerase chain reaction.
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How to cite this article: Garg D, Maheshwari RK, Raina D, Prevalence of blaKPC Gene in Carbapenem-Resistant Klebsiella pneumoniae Isolated from Clinical Samples of a Tertiary Care Hospital. Int J Drug Deliv Technol. 2026;16(4s): 866-872; DOI: 10.25258/ijddt.16.4s.100
Source of support: Nil
Conflict of interest: None