International Journal of Drug Delivery Technology
Volume 16, Issue 4s

Evaluation Of Neutrophil-To-Lymphocyte Ratio As A Biomarker For Chronic Inflammation In Type2 Diabetes Mellitus

Dr NAVANEETH K N1*, Dr Jamuna B L2, Dr Priyanka Singh3

1*Post Graduate Final Year, Department of Physiology, Rajarajeswari Medical College and Hospital, Dr MGR Educational and Research Institute, Bangalore, India

(Corresponding Author)
2Professor, Department of Physiology, Rajarajeswari Medical College and Hospital, Dr MGR Educational and Research Institute, Bangalore, India
3Professor and HOD, Department of Physiology, Rajarajeswari Medical College and Hospital, Dr MGR Educational and Research Institute, Bangalore, India

ABSTRACT

BACKGROUND: Type 2 diabetes is on the rise worldwide that can cause complications in long term or uncontrolled diabetes mellitus. Inflammatory processes have a significant role in the onset and progression of type 2 diabetes. Leukocytes, including Neutrophil-to-Lymphocyte Ratio (NLR) have been identified as novel markers of inflammation. Neutrophil-to-Lymphocyte Ratio (NLR) has lately become a prominent inflammatory marker, and studies have shown that a high NLR negatively influences the prevalence and prognosis of coronary artery disease.

AIMS & OBJECTIVES: To assess the correlation between NLR and glycaemic control in T2DM patients.

MATERIALS & METHODS: A hospital-based cross-sectional study was carried out amongst 60 T2DM patients, wherein NLR measured from venous blood samples. HbA1c estimated using HPLC method. Pearson's correlation was used to analyse the relationships between HbA1c and NLR with a p-value < 0.05 considered statistically significant.

RESULTS: The mean age of our study subjects was found to be 54.25 ± 8.50 yrs. Our study population showed a clear male predominance, with a male-to-female (M:F) ratio of 1:0.57. Further, we found the mean BMI to be 27.95 ± 4.02 kg/m². 55 patients were found to have HbA1c level above 6.5%. 49 patients had a normal NLR value, whereas 11 patients had an NLR value above 3.50. It is observed that increasing HbA1c levels found to correlate strongly with increase in NLR Ratio.

CONCLUSION: There was a significant positive correlation between the Neutrophil-to-Lymphocyte Ratio and HbA1c levels in type 2 diabetes mellitus patients. Higher NLR was linked to poor glycaemic control, indicating its role as an independent marker of inflammation. We conclude NLR as a reliable, easily available, cost-effective marker which can forecast systemic inflammation in a variety of chronic inflammatory disorders.

Keywords: Glycaemia, Neutrophil Lymphocyte Ratio, Diabetes Mellitus, Neutrophil, Lymphocyte

How to cite this article: Navaneeth KN, Jamuna BL, Singh P, Evaluation Of Neutrophil-To-Lymphocyte Ratio As A Biomarker For Chronic Inflammation In Type2 Diabetes Mellitus. Int J Drug Deliv Technol. 2026;16(4s): 937-943; DOI: 10.25258/ijddt.16.4s.109

Source of support: Nil

Conflict of interest: None