1aR&D Scientist-II, Tulex Pharmaceuticals Inc., 5 Cedarbrook Drive, Cranbury, New Jersey, 08512, USA
1bDepartment of Pharmacy, University College of Technology, Osmania University, Hyderabad-500007, Telangana, India
2Professor, Department of Pharmaceutics, SRM College of Pharmacy, Faculty of Medicine and Health Sciences, SRM Institute of Science and Technology, Kattankulathur, Tamilnadu-603203, India
3*Associate Professor, Department of Pharmaceutics, SRM College of Pharmacy, Faculty of Medicine and Health Sciences, SRM Institute of Science and Technology, Kattankulathur, Tamilnadu-603203, India
Email: pnramya372@gmail.com
4Research Scholar, Department of Pharmaceutics, SRM College of Pharmacy, Faculty of Medicine and Health Sciences, SRM Institute of Science and Technology, Kattankulathur, Tamilnadu-603203, India
For medications that are poorly soluble, the cilnidipine microsphere created in this work provides an efficient drug delivery method. It is conceivable to conclude that Cilnidipine microspheres can effectively manage hypertension and assist obtain the full therapeutic advantage of calcium channel blockers in a clinical context. In this study, cilnidipine polymeric microspheres were made using the ionic gelation process. After that, polymeric microspheres were added to gellan gum gel and applied to the buccal cavity. The micromeritics properties, particle size, surface morphology characteristics, percentage drug entrapment efficiency, in-vitro drug release, and permeation studies of Cilnidipine-loaded polymeric microspheres were then evaluated. A comparative in-vitro drug release study was conducted using commercially available formulations of Cilacar and Dilnip tablets. Additionally, the appearance, pH, viscosity, refractive index, and spreadability of gellan gum were described.
To determine how different factors affected particle size, drug entrapment percentage, and drug release, optimization of drug-loaded polymeric microspheres was done. Consequently, it was shown that the biopolymeric carrier synthesized with BSA for the sustained release distribution of Cilnidipine had a sufficient drug entrapment efficiency of 96.7% w/v and a drug release rate of 93.3% w/v. Thus, the novel formulation of BSA-Cilnidipine offers a more recent extension of action that can be used to treat hypertension.
Keywords: N/A.
How to cite this article: Sura RS, Sangeetha S, Remya PN, Ranjani PS. An Assessment and Comparison of Cilnidipine-Loaded Bovine Serum Albumin and Egg Albumin Microsphere Formulations. Int J Drug Deliv Technol. 2026;16(4s): 44-52; DOI: 10.25258/ijddt.16.4s.5
Source of support: Nil.
Conflict of interest: None