Fibromyalgia (FM) is a chronic nociplastic pain marked by widespread pain, persistent fatigue, sleep disruption, and cognitive difficulties. Current evidence suggests that its pathophysiology is largely driven by central nervous system dysfunction, with altered pain processing and impaired communication across brain–behavior–immune networks. FM affects women disproportionately. Worldwide prevalence estimates vary, ranging from 0.2% to 6.6% in the general population and from 2.4% to 6.8% among women. Longitudinal studies highlight considerable variability in clinical course, with 20–47% of patients no longer meeting diagnostic criteria within one to two years.
Keywords: Fibromyalgia; Nociplastic pain; Neuroimmune interaction; Central sensitization; Women's health; Neuroplasticity
How to cite this article: Abdulbaqi AA, Fibromyalgia in Women: A Brain–Behavior–Immune Perspective on Global Prevalence, Neurobiological Plasticity, and Recovery Trajectories. Int J Drug Deliv Technol. 2026;16(4s): 861-865; DOI: 10.25258/ijddt.16.4s.99
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