1 Department of Pharmaceutics, College of Pharmacy, Al-Zahraa University for Women, Iraq
2 Department of Pharmaceutics, College of Pharmacy, University of Kerbala, Iraq
3 College of Pharmacy, Al-Masreq University
* Corresponding Author: qasim.allawi@alzahraa.edu.iq
Background:
Ondansetron tablets are widely used for the management of nausea and vomiting associated with chemotherapy, radiotherapy, and postoperative conditions. The quality and performance of these tablets depend on their physicochemical properties, which may vary among different marketed brands.
Objective:
This study aimed to evaluate and compare the physicochemical properties of selected ondansetron tablet brands marketed in Iraq.
Methods:
Six commercially available brands of ondansetron tablets (8 mg) were evaluated using standard pharmacopeial methods. The tests included weight variation, friability, hardness, tensile strength, disintegration time, and in vitro dissolution. All experiments were performed using ERWEKA equipment, and the results were expressed as mean ± standard deviation.
Results:
All tested brands complied with pharmacopeial limits for weight variation and friability (<1%). Significant differences were observed in hardness and disintegration time among the brands. Ondalek® showed the highest crushing strength, while Vomot® exhibited the fastest disintegration and dissolution rate. Variations in dissolution profiles were observed among the formulations, indicating differences in drug release behavior.
Conclusion:
The evaluated ondansetron tablet brands demonstrated acceptable quality; however, variations in physicochemical properties and dissolution behavior were observed. These differences may influence drug performance and highlight the importance of routine in vitro evaluation of marketed pharmaceutical products.
Keywords: Ondansetron; Tablets; Physicochemical evaluation; Dissolution test; Disintegration; Friability; Pharmaceutical quality; Iraq
How to cite this article: Bader QA, Ashoor JA, Jabbar MJ, Sanad WG. Comparative in Vitro Evaluation of Selected Ondansetron Tablet Brands Marketed in Iraq. Int J Drug Deliv Technol. 2026;16(5): 127-130. DOI: 10.25258/ijddt.16.5.13
Source of support: Nil.
Conflict of interest: None