1 Junior Resident, Department of Pathology, Sree Balaji Medical College and Hospital, Chrompet, Chennai - 44
2* Associate Professor, Department of Pathology, Sree Balaji Medical College and Hospital, Chrompet, Chennai - 44. Email: drpreethi1290@gmail.com (Corresponding Author)
3 Assistant Professor, Department of Pathology, Tagore Medical College and Hospital, Chennai - 600127
4 Professor, Department of Pathology, Sree Balaji Medical College and Hospital, Chrompet, Chennai - 44
Objective:
To describe the clinicopathological features, diagnostic challenges and management of endometrial carcinosarcoma presenting with unusual clinical manifestations.
Methods:
Patients presenting with abnormal uterine bleeding underwent clinical evaluation, imaging and pipelle biopsy. Histopathological examination with immunohistochemistry, including p53, cytokeratin and SMA, was performed. Multidisciplinary management with chemoradiotherapy followed by interval surgery was undertaken.
Results:
Histology revealed a biphasic malignant tumor with carcinomatous and sarcomatous differentiation, including heterologous elements. Immunohistochemistry confirmed epithelial and mesenchymal components with high proliferative activity. All patients showed favorable response to neoadjuvant therapy, allowing subsequent surgical staging and cytoreduction.
Conclusion:
Endometrial carcinosarcoma can mimic benign conditions, making early diagnosis difficult. Histopathology supported by immunohistochemistry is essential. Combined modality treatment may improve operability and outcomes.
Keywords: Endometrial carcinosarcoma; biphasic tumor; immunohistochemistry; p53; cytokeratin; SMA
How to cite this article: Thillaikkarasi S, Preethi M, Fathima MN, Lilly M. Endometrial Carcinosarcoma: An Unusual Presentation. Int J Drug Deliv Technol. 2026;16(5): 148-154. DOI: 10.25258/ijddt.16.5.17
Source of support: Nil.
Conflict of interest: None