International Journal of Drug Delivery Technology
Volume 16, Issue 5, 2026

Comparison of different medications delivery systems in peri implantitis treatment

Jeevan Shetty1, Munaz Mulla2*, Shyam Shahabuteen M3, Aditi De4, Jyoti Bisht5, Mushir Mulla6

1 Professor and Head, Department of Periodontics and Implantology, KGF College of Dental Sciences, Karnataka, India

2* Adjunct Professor, Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India. Email: drmunazperio@gmail.com / anilkk44@gmail.com (Corresponding Author)

3 Senior Lecturer, Department of Periodontics and Implantology, KGF College of Dental Sciences, Karnataka, India

4 Intern, Kalinga Institute of Dental Sciences, KIIT, Deemed to be University, Patia, Bhubaneswar-751024, Odisha, India

5 Assistant Professor, Department of Oral Medicine and Radiology, Santosh Dental College and Hospital, Ghaziabad, UP, India

6 Adjunct Professor, Global Research Cell, Dr. DY Patil Dental College Hospital, Dr. DY Patil Vidyapeeth (Deemed to be University), Pune-411018, Maharashtra, India

Received: 28th Feb, 2026; Revised: 6th March 2026; Accepted: 7th April, 2026; Available Online: 20th April, 2026

ABSTRACT

This paper compared minocycline microspheres, Metronidazole and 2.5mg of Chlorhexidine gluconate as drug delivery systems in the management of peri-implantitis. The experiment was made up of 45 people split into 3 equal categories as; Group I- Minocycline, Group II- Metronidazole and Group III- Chlorhexidine gluconate. At Baseline, 1, 3 and 6 months, clinical evaluation of bleeding on probing (BOP), probing pocket depth (PPD), clinical attachment level (CAL). Minocycline microspheres were done. There was significant improvements at follow-up using Minocycline followed by chlorhexidine and metranidazonein in POB, PPD, CAL at 1-6 months of recall.

Keywords: Local drug delivery, chlorhexidine, peri-implantitis

How to cite this article: Shetty J, Mulla M, Shahabuteen SM, De A, Bisht J, Mulla M. Comparison of different medications delivery systems in peri implantitis treatment. Int J Drug Deliv Technol. 2026;16(5): 8-11. DOI: 10.25258/ijddt.16.5.2

Source of support: Nil.

Conflict of interest: None