1 Department of Pharmaceutical Chemistry, UIPS, Chandigarh University, Mohali-140413, Punjab, India.
* Corresponding Author: S Shehensha
Thymoquinone (TQ), a physiologically active chemical found in Nigella sativa, sometimes referred to as black seed, has strong anti-inflammatory, antioxidant, and anticancer effects. However, its low solubility, volatility, and restricted bioavailability render it unfeasible. Distribution tactics based on nanotechnology have shown promise in improving the pharmacokinetic potential of thymoquinone (TQ) in order to get beyond these restrictions. In addition to lowering systemic toxicity, nano formulations such as polymeric, liposomal, chitosan and metal nanoparticles have demonstrated enhanced anticancer activity against ovarian, lung, colon and breast cancers. By regulating important signaling pathways such as P13K/Akt, NF-kB, and VEGF, TQ-loaded nanoparticles have been demonstrated in preclinical in vitro and in vivo investigations to induce apoptosis and limit tumor growth, angiogenesis and metastasis. Thymoquinone also enhances the effectiveness of chemotherapy treatments and reduces drug-induced toxicities. Thus, thymoquinone nano-encapsulation is a new and intriguing approach to tailored treatment and precision oncology.
Keywords: Nigella sativa, Thymoquinone, Nanotechnology, Nano formulations, Cancer Therapy, oncology.
How to cite this article: Pathania I, Shehensha S. A Comprehensive Review on Nano formulations of Thymoquinone for Cancer Management: Recent Progress and Future Perspectives. Int J Drug Deliv Technol. 2026;16(5): 184-198. DOI: 10.25258/ijddt.16.5.21
Source of support: Nil.
Conflict of interest: None