1 Assistant Professor, Chandigarh University, UIPS, Mohali, Punjab
2 Assistant Professor, Chandigarh University, UIPS, Mohali, Punjab
* Corresponding Author: shahenshah7@gmail.com
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease in which there will be gradual damage to the upper and lower motor neurons causing paralysis and death. The pathogenesis includes motor neuron degeneration, oxidative stress and neuroinflammation. Recent advances in the study of ALS focus on the therapeutic agents, including glycosides, that act as neuroprotective and anti-inflammatory agents. This review focuses on the efficacies of glycosides that includes madecassoside, ampelopsin, epigallocatechin gallate (EGCG), picroside-II, and so on based on the in vivo and in vitro studies. These compounds show promise with their ability to reduce oxidative stress, improve neuronal survival and regulate inflammatory pathways. Despite these promising preclinical results further clinical investigations are important to confirm these results and develop glycosides as potential ALS treatments.
Keywords: Amyotrophic Lateral Sclerosis, Glycosides, Neuroprotection, Oxidative Stress, Neuroinflammation
How to cite this article: Swathy SP, Shehensha S, Shefali M. Exploring Glycosides as Novel Therapeutic Candidates for Amyotrophic Lateral Sclerosis: A Comprehensive Review. Int J Drug Deliv Technol. 2026;16(5): 406-413. DOI: 10.25258/ijddt.16.5.43
Source of support: Nil.
Conflict of interest: None