a Assistant Professor, Institute of Pharmaceutical Research, GLA University, Mathura-281406, Uttar Pradesh, India
b Institute of Pharmaceutical Research, GLA University, Mathura-281406 (U.P.) INDIA
b* Corresponding Author: Email: gopalprasad.agrawal@gla.ac.in / gopalbobby91@gmail.com
Plants that have an extensive history of being utilized in traditional medicine make a logical choice for scientific research. Whether the traditional applications are backed by real biological effects or are solely based on folklore is a fascinating issue to consider. Skin infections caused by fungi can occasionally worsen when they penetrate the third layer of skin. It has been demonstrated that a few plant extracts and some essential oils have strong antifungal effects. The present study successfully investigated for the initial the therapeutic potential of alpha-terpinyl acetate loaded micelles nano particles, resulting in the percent permeation cumulative amount alpha-terpinyl acetate permeated via dialysis membrane and porcine skin from micellar gel was 86.5 % higher than miconazole nitrate and also anti fungal activity was 50.1 % higher than miconazole nitrate. Amphiphilic copolymer molecules often self-assemble into block copolymer micelles in an aqueous environment. Hydrophilic blocks create the micelle corona (or shells), whereas hydrophobic blocks create the micelle cores (or polyion complexes). Due to the solubilization of lipophilic medicines in the hydrophobic micelle cores, drug concentration in an aqueous environment is significantly increased. This gives bioactive molecules fresh life after being abandoned due to their poor water solubility.
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How to cite this article: Singh V, Agrawal GP. Alpha-terpinyl acetate: Novel Pluronic-127 Nano micelles for anti-fungal drug delivery. Int J Drug Deliv Technol. 2026;16(5): 56-60. DOI: 10.25258/ijddt.16.5.6
Source of support: Nil.
Conflict of interest: None