1 School of Pharmaceutical Sciences, Shri Guru Ram Rai University, Patel Nagar, Dehradun-248001 Uttarakhand, India
2 School of Pharmaceutical Sciences and Technology, Sardar Bhagwan Singh University, Dehradun-248001, Uttarakhand, India
Email: bishtlata155@gmail.com, neeraj_sidana2007@rediffmail.com (Corresponding Author), vrgodara@gmail.com (Corresponding Author)
ORCID ID: 0000-0002-9298-681X, 1*ORCID ID: 0000-0002-5584-8522, 2*ORCID ID: 0000-0002-7564-2601
Background:
Diabetic cognitive impairment is a metabolic neurodegenerative disorder associated with central nervous system. Unfortunately, there is no effective means by which to delay the cognitive symptoms of DM. Considering these limitations, there has been growing interest in investigating herbal alternatives for managing diabetes associated with cognitive deficit.
Objective:
To investigate the neuroprotective role of methanolic leave extract of Allium stracheyi (MLEAS) Baker in diabetic rats.
Materials and Methods:
Diabetes in rats were induced by 10% fructose solution for 14 days and single administration of streptozotocin (40mg/kg) in G2-G6 followed by 28 days treatment with glibenclamide (10mg/kg) and MLEAS at dose 100, 200 and 400mg/kg respectively. Vehicle control G1, received no treatment. Body weight, serum glycemic index, insulin marker, lipid indices, oxidative stress were evaluated using standard procedure. Neurobehavioural responses were measured using Elevated-Plus (EP) and Morris-Water (MW) Maze followed by estimation of acetylcholinesterase level. Pancreatic and brain tissue were retrieved for histopathological study.
Results:
MLEAS significantly reinstated the body weight, fasting blood sugar, insulin resistance, lipid indices in diabetic rats. MLEAS, increased the glutathione (GSH) and superoxide dismutase (SOD) whereas decreases malondialdehyde (MDA) and nitric oxide (NO) levels. Furthermore, the AchE level was also resorted suggesting attenuation of cognitive impairment.
Conclusion:
Overall findings showed that MLEAS exhibit neuroprotective effect against diabetes associated cognitive deficit. Thereby, opening new avenues for future research, which aim in developing potential compounds for effective disease management. Therefore, the plant emerges as a promising candidate that warrants further investigation to improve overall quality of life.
Keywords: Diabetes, Cognition, Neuroprotective, Disease, Antioxidant.
How to cite this article: Bisht L, Kumar N, Ram V. Amelioration of Diabetes-Induced Cognitive Dysfunction by Allium stracheyi in Rats. Int J Drug Deliv Technol. 2026;16(5): 61-78. DOI: 10.25258/ijddt.16.5.7
Source of support: Nil.
Conflict of interest: None