1* Mizoram Varigeti, Assistant Professor, Department of Anatomy, Saheed Laxman Nayak Medical College& Hospital, Koraput, Odisha; PhD Scholar Sri Balaji Vidyapeeth (Deemed-to be-University), Pondicherry.
2 Dr Chandra Philip X, Professor Department of Anatomy, Mahatma Gandhi Medical College &Research Institute, Sri Balaji Vidyapeeth (Deemed-to-be university), Pondicherry
3 Dr Sujata Swain, Professor & HOD, Department of Obstetrics & gynaecology Saheed Laxman Nayak Medical College& Hospital, Koraput, Odisha
4 Dr Sadananda Rath, Professor & HOD, Department of Anatomy, Saheed Laxman Nayak Medical College& Hospital, Koraput, Odisha.
5 Dr M H R K Gupatha Bayya, Professor, Department of Pharmacology, Rohilkhand Medical College & Hospital, Affiliated to Bareilly International University, Bareilly, Uttar Pradesh
Background: The placenta is vital fetomaternal organ that sustains pregnancy and promotes optimal neonatal outcomes. Evidence suggest that preeclampsia is associated with architectural and functional changes in the placenta, which may eventually influence the intrauterine foetal development. Aim: This study is intended to explore placental morphological changes in preeclampsia pregnancies and to evaluate their association with fetal outcomes in comparison with normotensive pregnancies. Methods: A total of 150 placentas were collected post-delivery from normotensive (n=75) and preeclampsia (n=75) pregnancy. Placental morphometric parameters including weight, diameter, thickness, radius, surface, volume and number of cotyledons and fetal weights were measured. Morphological features such umbilical cords as insertion and the presence of placental infarcts were also documented. Comparative analyses between groups were performed using the unpaired Student’s t-test and Chi-square test with SPSS software. Results: Placentas from preeclampsia pregnancies exhibited significant (p ≤0.001) reductions in weight (360.09 ± 74.89 vs 471.25 ± 79.68), index ( 0.170 ± 0.032 vs 0.167 ± 0.033), diameter (15.81 ± 1.55 vs 18.21 ± 1.26), thickness (1.83± 0.46 vs 2.45 ± 0.43), radius (7.90 ± 0.77 vs9.11 ± 0.63), surface area (197.93 ± 37.91 vs 261.82 ± 36.45), volume (370.98 ± 139.73 vs 646.08 ± 162.94) and number of cotyledons (16.37 ± 2.03 vs 18.13 ± 1.71) as compared to normotensive pregnancy. Placental infarctions were significantly (p ≤0.001) higher in preeclampsia. Most placentas in the normotensive group weighted between 401-500 g, whereas preeclamptic group, weights predominantly ranged from 301-400 g. Additionally, fetal birth weights were significantly (p ≤0.001) lower in preeclamptic pregnancies (2008.36 ± 309.61 vs 2708.29 ± 392.78) with respective to normotensive pregnancy. Conclusion: Study confirms that preeclampsia is associated with significant changes in both placental morphology and morphometry. It’s concluded that, these definitive changes likely to impair placental function contributing to reduced uteroplacental perfusion and nutrition, consequently, lower fetal birth weight. . .
Keywords: Placenta Morphology, Morphometry, Fetal weight, Preeclampsia .
How to cite this article: Varigeti M, Philip X C, Swain S, Rath S, Gupatha Bayya MHRK. Correlation of Placental Morphological changes with Neonatal Outcomes: An Observational Study of Normotensive and Preeclampsia. Int J Drug Deliv Technol. 2026;16(56s): 811-818. DOI: 10.25258/ijddt.16.56s.88
Source of support: Nil.
Conflict of interest: None.