1Research Scholar, Dr. Yellapragada Subba Rao Research center, Dr. Samuel George Institute of Pharmaceutical Sciences, Markapuram, Andhra Pradesh, India, aku.phd2023@gmail.com
2Professor and HOD, Dept. of Pharmacognosy, Dr. Yellapragada Subba Rao Research center, Dr. Samuel George Institute of Pharmaceutical Sciences, Markapuram, Andhra Pradesh, India, kasaralasuresh@gmail.com
There is a vast knowledge on medicinal plants acting on neurological disorders deposited in the Ayurvedic system. This system is being validated increasingly in recent times with the modern techniques to prove the safety and efficacy. Phytochemicals derived from plants such as Withania somnifera (Ashwagandha), Bacopa monnieri (Brahmi), and Centella asiatica (Gotu kola) have been shown to exert multifaceted effects, including antioxidant, anti-inflammatory, neuroprotective, and psychotropic actions. These properties align closely with their traditional Ayurvedic roles as Rasayana (rejuvenators) and cognitive enhancers. Advanced computational approaches—such as molecular docking, molecular dynamics simulations, and network pharmacology—have revealed the polypharmacological nature of these compounds, demonstrating their ability to interact with multiple targets simultaneously, including neurotransmitter receptors, cholinesterases, amyloid-beta, and tau proteins. Neurobehavioral models further strengthen this evidence by linking molecular mechanisms to observable improvements in cognition, mood, and stress resilience. Clinical trials conducted in recent years confirm these findings, showing significant benefits in anxiety reduction, memory enhancement, sleep quality, and overall mental health. This multifaceted analysis underscores the importance of integrating traditional knowledge with modern biomedical science. Future directions include the application of multi-omics technologies, artificial intelligence-driven modeling, and large-scale randomized controlled trials to establish standardized dosing, safety profiles, and personalized interventions. Together, these efforts highlight the growing relevance of Ayurvedic phytochemicals in contemporary healthcare. By bridging ancient wisdom with modern pharmacology, Ayurveda offers a holistic and evidence-based framework for addressing complex neurobehavioral disorders and advancing global nutraceutical innovation.
Keywords: Ayurveda; Phytochemicals; Neuroprotection; Network Pharmacology.
How to cite this article: Sivaji K, Suresh K, Indian Medicinal Plants in Neurobehavioral Research: A Multi-Faceted Review of Pharmacological Insights and Computational Modelling Approaches. Int J Drug Deliv Technol. 2026; 16(5s): 925-929; DOI: 10.25258/ijddt.16.5s.113
Source of support: Nil.
Conflict of interest: None