Severe Digital Ischemia and Necrosis in Mixed Connective Tissue Disease: A Case of Secondary Raynaud's Phenomenon Leading to Digital Shortening

Dr. Bidisha Borthakur1, Dr. N.N. Anand2*, Dr. Divya Sriramulu3, Dr. S. Nava Mallika Sreya4 and Dr. AB. Adit Mithilesh5

1Junior resident, Department of General Medicine, Sree Balaji Medical College and Hospital
2HOD, Department of General Medicine, Sree Balaji Medical College and Hospital
3Assistant Professor, Department of General Medicine, Sree Balaji Medical College and Hospital
4Junior resident, Department of General Medicine, Sree Balaji Medical College and Hospital
5Junior resident, Department of General Medicine, Sree Balaji Medical College and Hospital
1bidishapgm@gmail.com, 2drnaganand1971@gmail.com, 3divyasriram21@gmail.com, 4sarvepallisreya@gmail.com and 5mithilesh.adit@gmail.com

Received: 16th Dec, 2025; Revised: 26th Jan 2026; Accepted: 12th Feb, 2026; Available Online: 28th Feb, 2026

ABSTRACT

We present the case of a 48-year-old female patient diagnosed with Mixed Connective Tissue Disease (MCTD) who developed severe secondary Raynaud's phenomenon. This complication resulted in critical digital ischemia and necrosis, specifically affecting the right ring finger, leading to digital shortening. Diagnosis was strongly supported by classic serological markers, including a positive Anti-Nuclear Antibody (ANA) test with a speckled pattern, high titres of Anti-Nucleosome antibodies, and definitive positivity for both RNP 68kd and Sm/RNP antigens. This report highlights the destructive potential of severe secondary Raynaud's in MCTD and the importance of timely diagnosis based on specific serological profiles.

Keywords: Mixed Connective Tissue Disease, Raynaud's phenomenon, Digital ischemia, Anti-U1 RNP antibodies, Connective tissue disorders

How to cite this article: Borthakur B, Anand NN, Sriramulu D, Nava Mallika Sreya S, Adit Mithilesh AB, Severe Digital Ischemia and Necrosis in Mixed Connective Tissue Disease: A Case of Secondary Raynaud's Phenomenon Leading to Digital Shortening. Int J Drug Deliv Technol. 2026;16(5s): 168-170. DOI: 10.25258/ijddt.16.5s.20