Biological Role of Metal Complexes and Applications

Aysel Rahimova1, Malahat Bagiyeva2, Samina Sultanova3, Tarana Qurbanova4, Saadat Mammadova5, Sevda Ismayilova6, Kamala Mustafayeva7

Department of General and Inorganic Chemistry, Faculty of Chemistry, Baku State University, Baku, Azerbaijan
1 https://orcid.org/0000-0002-9516-0589, 2 https://orcid.org/0009-0001-8619-8059, 3 https://orcid.org/0009-0001-6109-4595, 4 https://orcid.org/0009-0001-2568-8521, 5 https://orcid.org/0009-0009-2319-7831, 6 https://orcid.org/0009-0004-2481-7485, 7 https://orcid.org/0009-0008-4738-5864
Corresponding Author: Aysel Rahimova: ayselrahimova@bsu.edu.az / rahimova_aysel@mail.ru

Received: 4th Nov, 2025; Revised: 24th Nov 2025; Accepted: 30th Nov, 2025; Available Online: 1st December, 2025

ABSTRACT

In this scientific research paper has described theoretical investigation of different metal complexes biological applications. It have been revealed that transition metals have shown many applications, such as anticancer, antimicrobial, anti-inflammatory properties. Depending on the structure of ligands transition metal complexes have shown antitumor properties. It have also been accomplished that not all iron containing complexes have shown anticancer properties, there is also iron containing complexes which increases cancer diseases or no anticancer effect. Here discussed that if ligands show anticancer property, adding metals in the structure of complex improves property. We have improved that many anticancer complexes in vivo level exposed hydrolyses decrease effect. It have discussed the reason of different metal complexes different properties ability forming complex with different ligands. We have concluded our thoughts most anticancer complexes are Pt, Fe, and Zn containing compounds. Cobalt containing complexes have shown moderate or no cancer property. Investigation of Nickel containing complexes is started recently. There are ligands containing nickel complexes shown anticancer property.

Keywords: complex compounds, transition metals, cancer treatment, antimicrobial properties SDG3, SDG12.

How to cite this article: Rahimova, A., Bagiyeva, M., Sultanova, S., Qurbanova, T., Mammadova, S., Ismayilova, S., & Mustafayeva, K.; Biological Role of Metal Complexes and Applications. Int J Drug Deliv Technol. 2026;16(5s): 213-226. DOI: 10.25258/ijddt.16.5s.25