Pigmented skin lesions present a significant diagnostic challenge due to the clinical overlap between benign entities and malignant neoplasms like melanoma. While melanocytic lesions are frequently discussed, pigmented lesions of keratinocytic origin are less common and require careful histopathological distinction. This case series details our experience with four cases of benign pigmented keratinocytic lesions diagnosed over two years at a tertiary care center. We present one case of cutaneous melanoacanthoma and three cases of pigmented seborrheic keratosis, highlighting their clinical presentation, distinctive histopathological features, and the critical role of microscopy in achieving an accurate diagnosis. The cases underscore the importance of differentiating these benign tumors from their malignant mimics, such as melanoma and pigmented squamous cell carcinoma, to guide appropriate management.
Keywords: Melanoacanthoma, Pigmented Seborrheic Keratosis, Keratinocytic Lesions, Histopathology, Differential Diagnosis
How to cite this article: Pazhambalacode VV, Lilly M, Gali V, Clinicopathological Spectrum of Pigmented Keratinocytic Lesions: A Case Series of Melanoacanthoma and Pigmented Seborrheic Keratosis. Int J Drug Deliv Technol. 2026;16(5s): 309-314; DOI: 10.25258/ijddt.16.5s.39
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Conflict of interest: None