Background: Internal medicine is increasingly challenged by rising multimorbidity, diagnostic complexity, and fragmented healthcare delivery. Traditional disease-centered models often fail to address individual biological variability and system-level inefficiencies.
Objective: This narrative review aims to explore how the integration of precision diagnostics with coordinated, multidisciplinary care can redefine internal medicine practice and improve clinical outcomes.
Methods: A narrative review of the literature was conducted using PubMed, Scopus, and Web of Science, focusing on studies published between 2010 and 2025. Key domains included precision diagnostics, integrated care models, artificial intelligence, and personalized medicine in internal medicine practice.
Results: Precision diagnostics—including genomics, advanced biomarkers, imaging, and artificial intelligence—enable individualized risk stratification and treatment selection. Integrated care models improve continuity, coordination, and patient engagement. However, when implemented in isolation, each approach has limited impact. Their integration offers a synergistic model that enhances diagnostic accuracy, therapeutic effectiveness, and healthcare efficiency.
Conclusion: The future of internal medicine lies in the strategic integration of precision diagnostics within comprehensive, patient-centered care systems. This paradigm shift positions internists as system integrators who translate complex diagnostic data into personalized, coordinated care pathways.
Keywords: Internal medicine, precision diagnostics, integrated care, personalized medicine, healthcare systems.
How to cite this article: Maghfuri AB, Al Assiri B, Alshehri DA, Alshahrahi MS, Abu Hasil MA, Alasmari AMM, Dajam KS, Tarig A, Fageer MA, Nabrawi YK. Redefining internal medicine through precision diagnostics and integrated care: a paradigm shift toward personalized, system-based practice. Int J Drug Deliv Technol. 2026;16(5s): 315-322; DOI: 10.25258/ijddt.16.5s.40
Source of support: Nil.
Conflict of interest: None