1Basic Doctorant, Samarkand State Medical University, Uzbekistan
2Doctor of Medical Sciences, Professor, Department of Pediatric Surgery No.1, Samarkand State Medical University, Uzbekistan
3Candidate of Medical Sciences, Assistant, Department of Pediatric Surgery No.1, Samarkand State Medical University, Uzbekistan
Background: Necrotising enterocolitis (NEC) is one of the most serious gastrointestinal emergencies in neonates, particularly in premature and low birth weight infants. Early diagnosis remains challenging because conventional clinical and radiological findings often appear after significant intestinal injury has occurred. Recently, biomarkers such as intestinal fatty acid-binding protein (I-FABP), fecal calprotectin, and physiological parameters like transvesical intra-abdominal pressure monitoring have been proposed for early detection of intestinal injury and inflammation associated with NEC.
Aim: To evaluate the diagnostic significance of serum I-FABP, fecal calprotectin, and transvesical intra-abdominal pressure monitoring in neonates with suspected necrotising enterocolitis.
Materials and Methods: A prospective observational study was conducted in the Department of Paediatric Surgery at a tertiary care hospital in Uzbekistan over a period of one year. A total of 60 neonates with suspected NEC were included in the study. Clinical features, gestational age, and birth weight were recorded. Serum I-FABP levels, fecal calprotectin levels, and transvesical intra-abdominal pressure were measured and analyzed. Statistical analysis was performed to determine the association of these parameters with NEC.
Results: The majority of neonates were premature and had low birth weight. Elevated serum I-FABP (>400 pg/mL) was observed in 38.3% of neonates, while fecal calprotectin levels >500 µg/g were noted in 45.0% of cases. Increased intra-abdominal pressure (>15 mmHg) was present in 31.7% of neonates. These findings showed statistically significant associations with necrotising enterocolitis (p < 0.05).
Conclusion: Serum I-FABP, fecal calprotectin, and transvesical intra-abdominal pressure monitoring are useful adjunctive tools for early detection and assessment of disease severity in neonates with necrotising enterocolitis.
Keywords: Necrotising enterocolitis, Intestinal fatty acid-binding protein, Fecal calprotectin, Intra-abdominal pressure, Neonates, Biomarkers.
How to cite this article: Maftuna F, Ostonoqulovich AJ, Prasenjit TS. I-FABP (Intestinal Fatty Acid Binding Protein), Fecal Calprotectin, Monitoring Transvesical Abdomen Pressure: New Diagnostic Criteria of Necrotising Enteritis. Int J Drug Deliv Technol. 2026;16(5s): 693-698; DOI: 10.25258/ijddt.16.5s.88
Source of support: None
Conflict of interest: None