1Junior Resident, Department of Biochemistry, Integral Institute of Medical Sciences and Research, Integral University, Lucknow, Uttar Pradesh, India
2Professor, Department of General Medicine, Integral Institute of Medical Sciences and Research, Integral University, Lucknow, Uttar Pradesh, India
3Associate Professor, Department of Microbiology, Integral Institute of Medical Sciences and Research, Integral University, Lucknow, Uttar Pradesh, India
4Professor, Department of Biochemistry, Integral Institute of Medical Sciences and Research, Integral University, Lucknow, Uttar Pradesh, India
*Corresponding Author: Dr. Furquan Alam
Email: furquan@iul.ac.in
Background: Type 2 diabetes mellitus (T2DM) is associated with systemic inflammation and atherogenic dyslipidemia. Neuregulin-4 (NRG-4), an adipokine involved in metabolic regulation, may play a role in lipid homeostasis and cardiometabolic risk modulation.
Objective: To assess serum NRG-4 levels and their correlations with lipid profile parameters in newly diagnosed T2DM patients compared with age- and gender-matched healthy controls.
Materials and Methods: Fifty newly diagnosed T2DM patients and 50 matched healthy controls were recruited over 18 months. Fasting blood samples were analyzed for glucose, HbA1c, lipid profile, and serum NRG-4 levels using ELISA. Statistical analyses included Student's t-test and Pearson correlation coefficient. A p-value < 0.05 was considered statistically significant.
Results: Cases and controls were comparable in age and gender. T2DM patients had significantly higher CRP (28.8 ± 14.4 vs 3.96 ± 1.9 mg/L) and HbA1c (7.1 ± 1.3% vs 5.3 ± 0.4%; p < 0.001). Lipid profiles demonstrated atherogenic dyslipidemia, with increased total cholesterol, triglycerides, LDL, and VLDL levels, along with reduced HDL cholesterol. Serum NRG-4 levels were significantly higher in T2DM patients (2.9 ± 1.0 vs 1.07 ± 0.4; p < 0.001) and showed significant negative correlations with triglycerides, LDL, and VLDL, and a positive correlation with HDL cholesterol.
Conclusion: Newly diagnosed T2DM patients exhibit systemic inflammation, dysglycemia, and atherogenic dyslipidemia. Elevated NRG-4 levels demonstrate significant associations with lipid parameters, suggesting its potential role as a biomarker in metabolic dysregulation and cardiovascular risk stratification.
Keywords: Type 2 diabetes mellitus, Neuregulin-4, lipid profile, atherogenic dyslipidemia, biomarker.
How to cite this article: Pal R, Katiyar V, Nadeem R, Alam F, Alam R, Iqbal S. Correlation of Neuregulin-4 (NRG-4) Levels with Lipid Profile in Newly Diagnosed Diabetes Mellitus Patients at Tertiary Care Centre. Int J Drug Deliv Technol. 2026;16(6s): 866-871; DOI: 10.25258/ijddt.16.6s.114
Source of support: None
Conflict of interest: None