1KJ's Trinity College of Pharmacy, Pune, India
2*Agricultural Development Trust's School of Pharmacy & Research Centre, Pune, India
Email: atul200678@gmail.com
3SB Patil College of Pharmacy, Indapur, Pune, Maharashtra, India
4Dr. B. B. Khaladkar College of Pharmacy, Wakhari, Kedgaon, Pune, Maharashtra, India
Stability of nanoparticles is a big issue for pharmaceutical applications due to aggregation. In these studies, we have studied and evaluated the effect of various drying methodologies like adsorption drying, freeze drying and vacuum drying along with excipients like adsorbents, cryoprotectants. The nature of formulation, its composition, conditions of drying and concentration of excipients used has found major effect in the drying processes. Results of screenings and evaluations of dried products obtained has suggested that freeze dried Eudragit®S-100 encapsulated retinol acetate nanoparticles (2/1, w/w, Drug (D) / Eudragit®S-100(E)) with mannitol 5%w/v as cryoprotectant was the best product. It was due to better redispersity with good flow properties. It has comparatively lower particle size of 200.1 ±15.8 nm, polydispersity index 0.446 ± 0.11, zeta potential -10.0 ± 0.39 mev and higher drug content 83.62 ± 0.5%.
Keywords: Nanoparticles, Adsorption Drying, Freeze Drying, Vacuum Drying, Adsorbents, Cryoprotectants, Stability, Screenings, Evaluations.
How to cite this article: Velhal MK, Baravkar A, Bodake PL, Bhalerao M. A Comparative Study of Drying Methodologies for Generation of Free Flowing Powder of Polymeric Nanodispersions. Int J Drug Deliv Technol. 2026;16(6s): 910-923; DOI: 10.25258/ijddt.16.6s.120
Source of support: None
Conflict of interest: None