1PhD research scholar, Index Medical College and Research centre, Indore, MP
Email: gyanendra02071995@gmail.com
2Professor, Department of Biochemistry, Index Medical College & Research Centre, Indore, MP
Email: Shreyanigoskar@gmail.com
3Assistant professor, Autonomous State Medical College, Sultanpur, Uttar Pradesh
Email: gkppratibha@gmail.com
Background: Many researches have implicated most of the prediabetic individuals to finally end up with the progression to diabetes and increase the risk of other life-threatening diseases. In progression of disease obesity plays a major role. This study earlier interventions involving changes in lifestyle dietary habits and physical activity (decreases production of proinflammatory molecules by reducing visceral fat and increases insulin sensitivity) in conjunction with the treatment modalities involving anti-inflammatory mechanisms that not only prevent the development and progression of diabetes (among high-risk groups) its associated complications, but also reduce the financial burden imposed on the diabetic patients.
Methodology: A total of 690 subjects, including 230 diagnosed T2DM cases, 230 pre diabetes mellitus and 230 healthy controls were selected for the research after the imposition of specific inclusion and exclusion criteria for controls, T2DM, and prediabetes. Fasting blood glucose level was the glucose oxidase-peroxidase (GOD-POD) method, using commercially available kit with semi-autoanalyzer machine. uric acid level was the uricase /POD method, using commercially available kit with semi-autoanalyzer machine. HbA1c level was the high-performance liquid chromatography (HPLC) and adiponectin, interleukin-6 level was the sandwich ELISA.
Results: The FBG, HbA1c, BMI, uric acid and IL-6 level were significantly higher in prediabetes and diabetes group compared with the those in the control group. The FBG, HbA1c, BMI, uric acid and IL-6 level were significantly higher in prediabetes and diabetes group compared with the those in the control group. There was no significant correlation between adiponectin level and FBG, HbA1c, BMI, uric acid and IL-6 in diabetes individuals. prediabetes individuals only significant correlation was between IL-6 and uric acid, BMI as well as FBG and BMI.
Conclusion: Biochemical markers helpful for marking severity of disease in an early phase of prediabetes. The early diagnosis of prediabetes is important in order to avoid long-term micro- and macro vascular complications in individuals at high risk of diabetes.
Keywords: HbA1c, FBG, Adiponectin, Uric acid, Interleukin-6
How to cite this article: Yadav G K, Nigoskar S, Tripathi P, Correlation of Serum Adiponectin with Uric Acid in Prediabetes and Type -2 Diabetes Mellitus. Int J Drug Deliv Technol. 2026;16(6s): 479-484; DOI: 10.25258/ijddt.16.6s.50
Source of support: Nil
Conflict of interest: None