1*Research Scholar, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology (CHARUSAT), CHARUSAT campus, Changa 388421, India
Email: saniprajapati@gmail.com
Phone: +91 9650407664
2*Associate Professor, Department of Pharmacology & Clinical Pharmacy, Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology (CHARUSAT), CHARUSAT campus, Changa 388421, India
Email: jalpasuthar.ph@charusat.ac.in
3Department of Diabetology, Rudraksh Institute of Medical Sciences, Ahmedabad, Gujarat, India
Background: To assess the prevalence of nonalcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes (T2D) and evaluate adverse drug reactions (ADR) associated with medications used to treat T2D and NAFLD.
Materials & Methods: A 2-year, observational ambispective study was conducted on 1500 patients with T2D. 621 T2D patients with NAFLD as comorbidity were evaluated and data on demographic characteristics, comorbidities, medications, and ADR were collected. The data was analysed descriptively using Microsoft Excel 365 software.
Results: In 1500 T2D patients, the prevalence of NAFLD is 41.4% (621) with higher in female (54.9%) than in males (45.1%). Prevalence of NAFLD was higher in 51-60 years age group (37.8%) and obese patients (62.0%). T2D patients with NAFLD have higher rate of ADR (34.8%) compared to without NAFLD (25.4%). ADR occurrence was higher in females (37.5%), obese (36.1%) and patients with two or more additional comorbidities (38.7%). Most prescribed class is biguanide followed by dipeptidyl peptidase-4 inhibitors, sulfonylureas, thiazolidinedione. 31 types of ADRs (368 incidents) were reported in 216 out of 621 T2D patients with NAFLD. Gastrointestinal disturbances, weakness, headache, tiredness, and hypoglycemic events were the most common ADRs. According to WHO-Uppsala Monitoring Centre (WHO-UMC) causality categories, ADRs were categorized as "Possible".
Conclusions: This study demonstrates higher prevalence of NAFLD in T2D patients particularly in females, older age groups and individuals with obesity. Although ADRs were mild to moderate in nature, treatment strategies will benefit from multicentre studies establishing comprehensive ADR database for T2D patients with NAFLD.
Keywords: ADR, Adverse drugs reaction, NAFLD, Nonalcoholic fatty liver disease, T2D, Type 2 diabetes.
How to cite this article: Prajapati S, Suthar J, Hasnani D, Chavda V. Prevalence of Nonalcoholic Fatty Liver Disease in Type 2 Diabetes Patients and Evaluation of Adverse Drugs Reactions: An Observational Ambispective Study. Int J Drug Deliv Technol. 2026;16(6s): 453-461; DOI: 10.25258/ijddt.16.6s.69
Source of support: Nil.
Conflict of interest: None