1Department of Pharmacy, IIMT College of Medical Sciences, IIMT University Meerut, Uttar Pradesh, India-250001
2Department of Pharmacy, Accurate College of Pharmacy, 49 Plot No, Knowledge Park III, Greater Noida, Uttar Pradesh-201306, India
Corresponding Author:
Ms. Lovely Chaurasia
Department of Pharmacy, IIMT College of Medical Sciences, IIMT University Meerut, Uttar Pradesh, India-250001
Email: join.sharma2606@gmail.com
Received: 05 Aug, 2025; Revised: 30 Oct, 2025; Accepted: 27 Dec, 2025; Available Online: 25 Jan, 2026
The skin acts as a vital protective barrier and plays a crucial role in maintaining homeostasis, sensory perception, and defense against external pathogens. Disruption of skin integrity results in wound formation, which may be acute or chronic depending on the healing duration. Chronic wounds, particularly those associated with conditions such as diabetes and vascular disorders, present significant therapeutic challenges. In recent years, hydrogels have emerged as promising wound-healing biomaterials due to their structural similarity to the extracellular matrix, high water retention, flexibility, and ability to deliver therapeutic agents. In the present study, chitosan and polyvinyl alcohol (PVA)–based hydrogel scaffolds loaded with 2-hydroxy-1,4-naphthoquinone were developed using a freeze-drying technique. Various scaffold formulations were prepared by altering chitosan:PVA ratios and were evaluated for particle size, entrapment efficiency, in-vitro drug release, rheological behavior, and physicochemical properties. Optimization was carried out using a Central Composite Design (CCD) to study the influence of polymer concentrations on particle size and entrapment efficiency. Among the formulations, F4 (chitosan:PVA, 2:1) exhibited the highest entrapment efficiency (92.45 ± 0.15%) with an optimal particle size (148 ± 0.15 nm). The optimized formulation demonstrated sustained drug release over 12 hours, suitable pH for topical application, good spreadability, homogeneity, and pseudoplastic rheological behavior. In vivo wound-healing and histopathological studies revealed enhanced re-epithelialization, collagen deposition, reduced inflammation, and improved granulation tissue formation in drug-loaded hydrogel–treated groups compared to controls. Overall, the developed chitosan/PVA hydrogel scaffold shows significant potential as an effective wound-healing system, offering sustained drug delivery, improved healing response, and favorable biocompatibility for topical applications.
Keywords: skin, wound-healing, spreadability, homogeneity, pseudoplastic, rheological behavior etc.
How to cite this article: Chaurasia L, Pande MS, Islam M. Formulation, Optimization and Evaluation of Wound Healing activity of Lawsone-loaded Scaffold based gel for Topical Delivery. Int J Drug Deliv Technol. 2026;16(6s): 562-568; DOI: 10.25258/ijddt.16.6s.81
Source of support: Nil.
Conflict of interest: None