1Department of Biochemistry, Chettinad Hospital and Research Institute, Chettinad Academy of Research & Education, Kelambakkam-603103, Tamil Nadu, India
1Mr Suresh Babu L M: saisureshss98@gmail.com ORCID: 0009-0007-4823-5967
1Dr. Rubisha RB: alicerubisha@gmail.com ORCID: 0009-0000-7595-4982
1*Dr. Anuradha Ganesan: anuradhasankar79@gmail.com ORCID: 0000-0002-5108-2486 (Corresponding Author)
Type 2 Diabetes Mellitus (T2DM) and hypothyroidism frequently coexist and contribute to a pro-inflammatory state, potentially complicating disease progression and management. This cross-sectional study aimed to evaluate the correlation between Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), and Thyroid-Stimulating Hormone (TSH) levels in individuals with T2DM and hypothyroidism. A total of 200 participants were enrolled, including 100 cases and 100 age- and sex-matched controls. NLR and PLR were significantly elevated in the case group, with a strong positive correlation observed between TSH and NLR (r = 0.558, p < 0.001), and a moderate correlation with PLR (r = 0.397, p < 0.001). ROC analysis showed good diagnostic performance for NLR (AUC = 0.795), while PLR showed limited discriminatory ability (AUC = 0.601). These findings suggest that NLR may serve as a reliable, low-cost inflammatory marker in T2DM patients with hypothyroidism.
Keywords: Type 2 Diabetes Mellitus, Neutrophil-to-Lymphocyte Ratio, Hypothyroidism.
How to cite this article: Suresh Babu LM, Rubisha RB, Ganesan A. Evaluation of NLR and PLR in T2DM with Coexisting Hypothyroidism and Their Correlation with TSH. Int J Drug Deliv Technol. 2026;16(6s): 578-582; DOI: 10.25258/ijddt.16.6s.83
Source of support: None
Conflict of interest: None