1Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pune-411018, Maharashtra, India
1*Dr Rashika, MBBS, Resident, Department of Paediatrics
Email: rashika200@gmail.com
1#Dr Mahenoor, MBBS, Resident, Department of Paediatrics (Corresponding Author)
Email: mahenoorkhan08@gmail.com
1Dr Sampada Tambolkar, MBBS, MD (Pediatrics), MHPE, Professor, Department of Paediatrics
Email: tambolkarsampada@gmail.com
1Dr. Shailaja Mane, MBBS, MD, PGDPC, PG Diploma in Adolescence, PG Diploma in Psychological Counseling, Professor and Head of Department of Paediatrics
Email: Shailaja.mane@dpu.edu.in
Severe dengue contributes significantly to morbidity and mortality in endemic regions of dengue which remains one of the fastest growing mosquito born viral infections. It is a critical clinical priority to identify reliable biomarkers for predicting disease progression. Vitamin D is known to be a potent immunomodulator playing role in influencing Dengue severity. We have systematically reviewed available evidences on association between dengue severity and serum 25-hydroxyvitamin D levels, and consequently evaluated various mechanistic hypothesis, identified challenges and future directions. Standard databases and literature search from 2010 to 2025 using predefined keywords were scrutinized. It was found that there is inconsistency in associations; several studies correlating vitamin D deficiency with sever dengue especially among paediatric population where as some studies reported elevated vitamin D in severe cases especially in secondary infections. The conflicting results may be attributed to several factors like study design, timing of Vit D measurement, generic variability, assay tests and immune status of individual. In order to clarify the prognostic utility of Vit D as standalone biomarker for dengue well designed, multicentric prospective studies and mechanistic investigations are required.
Keywords: Vitamin D, Dengue, Severity, Biomarker, Immunity.
How to cite this article: Rashika, Mahenoor, Tambolkar S, Mane S. Vitamin D as Biomarker of Sever Dengue: Evidence, Gaps, and future Directions. Int J Drug Deliv Technol. 2026;16(6s): 583-588; DOI: 10.25258/ijddt.16.6s.84
Source of support: None
Conflict of interest: None