*Corresponding Author: Deepak Prajapati, Research Scholar, Department of Pharmacy, SAGE University, Indore, Madhya Pradesh, India. Email: dsp7229@gmail.com
The current study intended to develop capsule formulations using isolated substances from Withania coagulans, Picrorhiza kurroa, and Gymnema sylvestre to achieve anti-diabetic formulations with enhanced oral hypoglycemic efficacy, reduced adverse effects, and improved patient adherence, thereby offering comprehensive advantages. Isolated fractions of selected plants were combined in a 1:1:1 ratio inside hard gelatin capsules. The preformulation of capsules was assessed by the angle of repose and bulk density. Completed capsule formulations were assessed for weight variation, pH, moisture content, disintegration time, in vitro drug release percentage, and in vivo antidiabetic investigations.
Our analysis revealed that the pH of the empty capsule shell was 3.62, and the moisture level of the capsule was less than 5% w/w, indicating a reduced likelihood of microbial development and preventing the capsule from becoming soft. The filled capsule met the criteria for weight consistency, and all capsules dissolved within seven minutes. The in-vitro dissolution investigation of the capsule yielded a result of 91.17%.
Keywords: Polyphenolic compounds, herbal formulations, Withania coagulans, Picrorhiza kurroa, Gymnema sylvestre, antidiabetic.
How to cite this article: Prajapati D, Goyanar G. Formulation of poly herbal capsule from ethanolic extract of Withania coagulans, Picrorhiza kurroa, and Gymnema sylvestre. Int J Drug Deliv Technol. 2026;16(7s): 109-115; DOI: 10.25258/ijddt.16.7s.14
Source of support: Nil.
Conflict of interest: None