Assessing the Efficacy of Postbiotics as a Chemopreventive Agent Against Colorectal Cancer: A Systematic Review

Rasika S ¹, Sindhu R ^2*, Gibbson Derick D ³, Lubna Fathima ⁴, Prabu D ⁵, Rajmohan M ⁶, Dinesh Dhamodhar ⁷

¹Undergraduate, SRM Dental College, Ramapuram, Bharathi Salai, Chennai, Tamil Nadu, India.

^2*,4MDS, Senior Lecturer, Department of Public Health Dentistry, SRM Dental College, Ramapuram, Bharathi Salai, Chennai, Tamil Nadu, India.
*Corresponding Author Email: researchphdsrm@gmail.com

³Postgraduate, Department of Public Health Dentistry, SRM Dental College, Ramapuram, Bharathi Salai, Chennai, Tamil Nadu, India.

⁵PhD, Head of the Department, Department of Public Health Dentistry, SRM Dental College, Ramapuram, Bharathi Salai, Chennai, Tamil Nadu, India.

^6,7MDS, Reader, Department of Public Health Dentistry, SRM Dental College, Ramapuram, Bharathi Salai, Chennai, Tamil Nadu, India.

*Corresponding Author: Dr. Sindhu R, MDS, Senior Lecturer, Department of Public Health Dentistry, SRM Dental College, Ramapuram, Bharathi Salai, Chennai, Tamil Nadu, India. Email: researchphdsrm@gmail.com

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ABSTRACT

Background: The incidence of cancer has been rising rapidly in recent years, Postbiotics shows promising therapy in preventing colorectal cancer. It includes wide range of complex macromolecules such as inactivated microbial cells, cellular fractions or metabolites and provide various physiological health benefits to host. They exert anti-inflammatory, anti-proliferative and anti-cancer properties.

Aim: This systematic review was conducted to evaluate the efficacy of postbiotics against colorectal cancer in animal study and in vivo study.

Materials and methods: In this study, Data extraction were searched and analyzed with PRISMA flow chart. Total of five articles were included for the study based on the inclusion and exclusion criteria. Quality assessment was done using the RoB 2 second version of Cochrane's risk of bias tool.

Results: The results of the systematic review indicate that postbiotics provides immune-modulating effects anti-proliferative, anti-inflammatory, apoptosis induce properties may contribute as chemo preventive agent for prevention of colorectal cancer.

Conclusion: Postbiotics may provide efficacy in anti-cancer properties and can be used as adjuvant therapy but more research is needed to confirm its efficacy and optimal usage. Further research and clinical trials are required to assess its therapeutic roles and safety in developing the outcomes of radiotherapy in cancer patients.

Keywords: Postbiotic, colorectal cancer, anti-proliferative, anti-inflammatory, immune mediating.

How to cite this article: Rasika S, Sindhu R, Derick GD, Fathima L, Prabu D, Rajmohan M, Dhamodhar D. Assessing the efficacy of postbiotics as a chemopreventive agent against colorectal cancer: a systematic review. Int J Drug Deliv Technol. 2026;16(7s): 199-208; DOI: 10.25258/ijddt.16.7s.23

Source of support: Nil.

Conflict of interest: None