*Corresponding Author: Dr. Noorul Rizwana A, MDS, Assistant Professor, Department of Prosthodontics and Implantology, SRM Dental College, Ramapuram, Bharathi Salai, Chennai, Tamil Nadu, India. Email: noorulra@srmist.edu.in, Contact: 9600039242
Critical-size bone defects caused by traumas, pathology or periodontal disease still persist as a leading cause of clinical challenge, which may involve giving grafting procedures to regain structure and functionality. The biological gold standard of grafts is considered autologous, because of their osteogenic nature- Osteo inductivemand osteoconductive, but the applications are restricted by the donor-site morbidity, limited availability of grafts and prolongation of operating time. Supply is relieved by allografts and xenografts but limiting factors contain threats of immunogenicity, disease transmission and ethics. Alloplastic grafts (hydroxyapatite ) including 3-calcium phosphate and bioactive Glass all provide sterile, biocompatible, and easily available substitutes; but, their osteoconductive properties are predominant leading to poor biological functionality. Recent progresses in regenerative medicine have introduced the use of herbal phytochemical in synthetic frameworks to improve biological activity. Phytoconstituents include: curcumin, Cissus quadrangularis and polyphenolic compounds demonstrating osteogenic, anti-inflammatory, antioxidant and pro-angiogenic functions. These molecules may be used to enhance greatly when incorporated into polymeric or ceramic alloplasts enhancing Cellular differentiation, vascularization and matrix mineralization, which essentially converts passive scaffolds into bioactive, biomimetic grafting systems. This is a review of the current evidence on the physicochemical properties of alloplastic materials, herbal functionalization methods and preclinical evidence of increased bone regeneration. Collectively, herbal-reinforced alloplasts are a new graft type that is less expensive, biologically responsive, and cost-effective, high-potential clinical translation substitutes.
Keywords: Herbal-Functionalized Alloplastic Grafts, Bone Tissue Engineering, Calcium Phosphate Biomaterials, Curcumin and Cissus quadrangularis, Bioactive Composite Scaffolds.
How to cite this article: Rizwana A N, Basha SG, Ravi A, Jasmeen, Vibitha, Hasifa M, Sasikala M. Herbal instillation of alloplastic bone grafting materials - a literature review on a new frontier in regenerative medicine. Int J Drug Deliv Technol. 2026;16(7s): 209-220; DOI: 10.25258/ijddt.16.7s.24
Source of support: Nil.
Conflict of interest: None