*Corresponding Author: Mohammed El-Mahdy Badra, M.B. B.CH, Ophthalmology, Faculty of Medicine, October 6 University, Giza, Egypt. Email: mohamedmahdi050@gmail.com
Background: Multiple sclerosis (MS) is a chronic inflammatory autoimmune disorder characterized by demyelination and axonal degeneration within the central nervous system. OCT and OCTA provide noninvasive methods for evaluating structural and vascular alterations in the optic nerve and retina, and they are increasingly utilized as biomarkers for monitoring disease progression in MS.
Aim: To evaluate optic nerve changes in MS individuals via OCT and OCTA.
Patients and methods: This is a cross-sectional study on MS individuals to evaluate optic nerve changes via OCT and OCT angiography. The study was executed at October 6 University Hospitals (Ophthalmology Department) over 6 months.
Results: Mean age was 31.9 ± 7.0 years; MS duration 3.38 ± 2.0 years. RNFL thickness averaged 98.5 ± 14.9 μm, with significant thinning in superior/inferior quadrants. GCC showed stronger positive correlations with EDSS scores (r=0.421, p=0.002) than RNFL. Angio disc density averaged 48.0 ± 4.6%, with no significant EDSS correlations. Reduced vessel density indicated early hypoperfusion.
Conclusion: OCT and OCTA reveal RNFL/GCC thinning and microvascular changes in MS, with GCC as a sensitive neurodegeneration biomarker. These metrics aid early detection and monitoring.
Keywords: Multiple Sclerosis, OCT Angiography, Optic nerve, EDSS.
How to cite this article: Moneer AH, Hassanien RM, Badra MEM. Optic nerve changes in multiple sclerosis patients attending outpatient clinic of October 6 University. Int J Drug Deliv Technol. 2026;16(7s): 397-404; DOI: 10.25258/ijddt.16.7s.41
Source of support: Nil.
Conflict of interest: None