1*Post Graduate Student, Nitte (Deemed to be University), AB Shetty Memorial Institute of Dental Sciences (ABSMIDS), Department of Periodontology, Mangalore, Karnataka - 575018, India. Email: nikita.hoskeri114@gmail.com ORCID: https://orcid.org/0009-0000-9053-5866 (Corresponding Author)
2Professor, Department of Periodontology and Implantology, Specialization: Periodontology and Oral Implantology, Government Dental College & Research Institute, Rajiv Gandhi University of Health Sciences, Karnataka - 560041, India. Email: ismail2220333@gmail.com ORCID: 0009-0001-6362-0902
3Senior Lecturer, Specialization: Oral and Maxillofacial Surgery, Department of Oral and Maxillofacial Surgery, Dayananda Sagar College of Dental Sciences, Bangalore - Affiliated to Rajiv Gandhi University of Health Sciences, Bangalore - 560111, Karnataka, India. Email: meghanapatil1997@gmail.com ORCID: 0009-0009-6509-024X
4Dentist, BDS, Social Dental Care Clinics. Email: ndmnazeer@hotmail.com
5Lecturer, Nitte (Deemed to be University), AB Shetty Memorial Institute of Dental Sciences (ABSMIDS), Department of Oral and Maxillofacial Surgery, Mangalore, India. Email: dranish.nelson@nitte.edu.in
6Senior Lecturer, Kalinga Institute of Dental Sciences, KIIT Bhubaneswar, Odisha, India. Email: noureen.nahar@kids.ac.in ORCID: 0009-0001-2555-649X
Bone regeneration plays a critical role in facial and skeletal reconstructive surgery by restoring structural integrity, functional stability, and aesthetic appearance following bone loss caused by trauma, tumor resection, congenital anomalies, or degenerative conditions. Traditional reconstructive methods, particularly autologous bone grafting, have long been considered the clinical standard due to their osteogenic potential and biological compatibility. However, limitations such as donor site morbidity, limited graft availability, and increased surgical complexity have encouraged the development of alternative regenerative approaches. Recent advances in biomaterials, tissue engineering, and regenerative medicine have significantly expanded the strategies available for bone repair. Synthetic bone substitutes, scaffold-based systems, and bioactive materials have demonstrated promising potential for supporting osteogenesis and improving integration with host bone. Additionally, emerging technologies such as stem cell–based therapies, growth factor delivery systems, and three-dimensional printing have introduced innovative solutions for managing complex craniofacial and skeletal defects. These approaches aim to enhance the biological microenvironment necessary for effective bone regeneration while improving functional and aesthetic outcomes. Despite these advancements, challenges related to biological variability, long-term stability, and clinical translation remain. This review evaluates current bone regeneration strategies used in facial and skeletal reconstructive surgery, compares conventional and advanced regenerative techniques, and highlights emerging technologies that may further improve reconstructive outcomes and guide future research in this rapidly evolving field.
Keywords: Bone regeneration, reconstructive surgery, biomaterials, tissue engineering, craniofacial reconstruction
How to cite this article: Hoskeri NN, B M, Patil MS, Nazeer N, Nelson A, Nahar N. Evaluation of Bone Regeneration Strategies in Facial and Skeletal Reconstructive Surgery: A Prospective Clinical Study. Int J Drug Deliv Technol. 2026;16(7s): 597. DOI: 10.25258/ijddt.16.7s.63
Source of support: Nil.
Conflict of interest: None