1*Junior Resident, Department of Anesthesia and Critical Care, Rajarshi Darshrath Autonomous State Medical College, Ayodhya, Uttar Pradesh, India (Corresponding Author)
Email: deepti.medico101095@gmail.com
2Assistant Professor, Department of Anesthesia and Critical Care, Rajarshi Darshrath Autonomous State Medical College, Ayodhya, Uttar Pradesh, India
3Professor and HOD, Department of Anesthesia and Critical Care, Rajarshi Dashrath Autonomous State Medical College, Ayodhya, Uttar Pradesh, India
Background: Spinal anaesthesia is one of the most commonly employed regional anaesthetic techniques for lower abdominal, obstetric, orthopaedic, and urological surgeries. The prolonged period and reliability of the sensory blockade have made it possible to recognize bupivacaine as the gold standard of the local anaesthetic to be employed in spinal anaesthesia. However, the cardiotoxicity and neurotoxicity issues associated with bupivacaine triggered the desire to have less toxic analogy such as levobupivacaine that is the pure S-enantiomer of bupivacaine.
Objective: This systematic review aims to compare the efficacy, safety, and haemodynamic effects of levobupivacaine and bupivacaine when used for spinal anaesthesia.
Methods: A systematic literature review was conducted in accordance with PRISMA guidelines. Studies published between 2022 and 2025 were identified from electronic databases and screened based on predefined inclusion and exclusion criteria of inclusion were randomised controlled trials, prospective comparative studies and review papers comparing levobupivacaine and bupivacaine in the spinal anaesthesia.
Results: Recent research has reported proof that levobupivacaine possesses comparable features in terms of sensory anaesthesia as compared to bupivacaine in terms of marginally lower motor block and improved haemodynamic stability. The reduced level of hypotension and cardiovascular adverse events in levobupivacaine is also suggested by other researches.
Conclusion: The Levobupivacaine is an alternative to bupivacaine which is the substitute anaesthetic agent that has the same effect as anaesthesia but has a superior safety profile. It could benefit the most the patients at riskier respect to cardiovascular diseases.
Keywords: Levobupivacaine, Bupivacaine, Spinal Anaesthesia, Local Anaesthetics, Systematic Review.
How to cite this article: Gautam DR, Sharma K, Tiwari JP. Comparison Of Levobupivacaine And Bupivacaine For Spinal Anaesthesia: A Systematic Review. Int J Drug Deliv Technol. 2026;16(7s): 619-629; DOI: 10.25258/ijddt.16.7s.66
Source of support: None
Conflict of interest: None