1*Padmashri Vikhe Patil College of Arts, Science and Commerce, Pravaranagar, Maharashtra, India
2*S.M.B.S.T. College of Arts, Science and Commerce, Sangamner, Maharashtra, India
3Amrutvahini College of Pharmacy, Sangamner, Maharashtra, India
4Agasti Arts, Commerce and Dadasaheb Rupwate Science College, Akole, Maharashtra, India
Savitribai Phule Pune University, Pune, Maharashtra, India
The utilization of compounds derived from natural sources represents a pivotal strategy in the development of effective and safe therapeutic interventions in human healthcare. Phytochemicals present in plants are increasingly acknowledged for their potential in the prevention of various human diseases. Abrus precatorius, commonly found in the tropical regions of the Western Ghats, exhibits several therapeutic properties. In this study, we systematically evaluated the chemical composition, antioxidant potential, and anti-inflammatory activity of the seeds from the black and white-yellow varieties of Abrus precatorius L. using an in vitro approach. This was achieved through successive extraction with n-hexane, ethanol, and aqueous Soxhlet. Phytochemical analysis via LC-MS revealed the presence of diverse secondary metabolites known for their biological activity. The concentration-dependent reduction of DPPH radicals was extensively investigated using in vitro biochemical methods, indicating the presence of effective free-radical neutralizing compounds. Mass spectroscopic analysis (LC-MS) demonstrated the presence of compounds such as Cortisone, 2-dimethylaminoethyl cinnamate, Ellipticine, Peonidin-3-O-glucoside, Diosmetin-7-O-rutinoside, Glabranin, 20-Hydroxyecdysone 20,22-acetonide, and Roemerine, which exhibited good binding scores and appreciable anti-inflammatory potential. The results indicate that A. precatorius seeds contain valuable natural antioxidants and anti-inflammatory compounds. The pharmacokinetic profiles of the active molecules were determined. The anti-inflammatory activity of the extracts was assessed using the bovine serum albumin (BSA) denaturation assay and the red blood cell membrane stabilization method. The black and white-yellow variety seeds of Abrus precatorius demonstrated notable inhibition of protein denaturation and effectiveness in stabilizing blood cell membranes, reflecting their ability to modulate inflammatory responses. Overall, our study reveals that the results support the therapeutic promise of Abrus precatorius seed extracts as a promising candidate for alleviating many health complaints associated with oxidative stress and inflammation. Further investigations are required to isolate the active constituents and establish their clinical relevance and safety.
Keywords: LCMS, DPPH, Abrus precatorius, Antioxidant, Antiinflammatory
How to cite this article: Randhawane JB, Borhade SS, Pandhre GR, Uphade BK, Raut DN, Naikwadi PH. Evaluation of the Chemical Composition, Antioxidant Potential and Anti-Inflammatory Activities Variety of Abrus Precatorius L. Seeds Extract. Int J Drug Deliv Technol. 2026;16(8s): 930-936; DOI: 10.25258/ijddt.16.8s.103
Source of support: Nil.
Conflict of interest: None