1Final year Student Department of Physiology, School of Medical Sciences and Research, Sharda University, Greater Noida, U.P., India.
2Professor, Department of Physiology, School of Medical Sciences and Research, Sharda University, Greater Noida, U.P, India.
3Assistant Professor, Department of Ophthalmology, NCR Medical College, Meerut.
4Professor & HOD, Department of Anatomy, School of Medical Sciences and Research, Sharda University, Greater Noida, U.P., India.
5Associate Professor, Department of Anatomy, School of Medical Sciences and Research, Sharda University, Greater Noida, U.P., India.
6Final Year Student Department of Pediatric & Preventive Dentistry, School of Dental Sciences & Research, Greater Noida, UP, India.
Background: Hypertension is a major universal health problem and a leading contributor to cardiovascular morbidity and mortality. Recent evidence suggests that systemic inflammation plays an important role in the pathogenesis of hypertension. Simple haematological markers, such as the Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR), have gained attention as cost-effective and easily accessible indicators of inflammatory status.
Objectives: This study aimed to compare NLR and PLR between hypertensive and normotensive individuals and to evaluate their association with blood pressure parameters.
Methods: A cross-sectional study was conducted among 128 adults attending Sharda Hospital, Greater Noida. Participants were categorized into hypertensive and normotensive groups. Complete blood counts were used to calculate NLR and PLR, and their relationship with systolic and diastolic blood pressure was analysed.
Results: The mean NLR and PLR were significantly higher in hypertensive individuals compared to normotensive controls (NLR: 5.65 ± 2.91 vs. 2.26 ± 0.93; PLR: 16.85 ± 12.10 vs. 8.83 ± 5.16; p < 0.001). Both NLR and PLR demonstrated a significant positive association with systolic and diastolic blood pressure.
Conclusion: Elevated NLR and PLR in hypertensive individuals highlight the role of systemic inflammation in hypertension. These inexpensive, readily available markers may aid in early detection, risk stratification, and hypertension monitoring in routine clinical practice.
Keywords: Hypertension, Neutrophil, Lymphocyte, Platelet, Inflammation.
How to cite this article: Zekpeh J, Rastogi S, Sharma S, Rohatgi R, Bharti A, Rastogi S. Evaluation Of Neutrophil To Lymphocyte Ratio And Platelet To Lymphocyte Ratio Among Hypertensive And Normotensive in adult population – A Cross-Sectional Study. Int J Drug Deliv Technol. 2026; 16(8s): 325-333; DOI: 10.25258/ijddt.16.8s.44
Source of support: Nil.
Conflict of interest: None