1Assistant Professor, Department of Biotechnology, Selvamm Arts and Science College (Autonomous), Namakkal-637003
2Associate Professor, Department of Botany, Rabindranath Tagore University, Dist. – Hojai
3Visiting Senior Lecturer, Department of Botany, Govt. Homescience PG Lead College, Narmadapuram (MP)
4*Assistant Professor, Department of Biochemistry (Faculty of Medical Sciences), Institute of Medical Sciences and SUM Hospitals II, Siksha 'O' Anusandhan (Deemed To Be University), Phulnakhara, Balianta, Bhubaneswar, Khordha, Odisha, India, Pin Code – 754001, Email - ranadevanr@gmail.com
The bioactive compounds found in herbs which include polyphenols and flavonoids show strong potential for medical use but their effectiveness is limited because they cannot dissolve in water and their molecules are too large and their substances cannot pass through cell membranes. The body shows very low absorption of these substances which leads to unpredictable medical results. Phytosome technology represents a major breakthrough in herbal medicine through its development of stoichiometric complexes which combine plant extracts with phospholipids. Phytosomes establish chemical connections through hydrogen bonding which enables phytoconstituents to attach to the polar phospholipid head. The combination process creates an amphiphilic molecule which results in better intestinal absorption and improved metabolic stability. The review presents an analysis of phytosome molecular structure and modern production methods and mathematical release patterns and the latest medical research from 2024 to 2026. The study investigates potential uses of phytosomes for targeted drug delivery and personalized medical treatments. Phytosomes provide a practical solution to enhance the medicinal power of herbal treatments because they boost the body's ability to absorb & process plant-based medicines. Through the process of encapsulating plant extracts within phospholipids phytosomes present an effective solution to the challenges faced by traditional herbal products. The pharmaceutical and nutraceutical industries currently use phytosomes for drug delivery but this field has the potential to create future advancements in their delivery systems.
Keywords: Phytosomes, Bioavailability enhancement, Herbal drug delivery, Phospholipids, Polyphenols.
How to cite this article: Prabhu R, Saikia M, Shrivastava R, Rajakumaravelu R. Phytosome-Based Drug Delivery System for Improved Bioavailability of Herbal Drugs. Int J Drug Deliv Technol. 2026; 16(8s): 385-389; DOI: 10.25258/ijddt.16.8s.51
Source of support: Nil.
Conflict of interest: None