1Amity institute of Pharmacy, Amity University, Raipur, Chhattisgarh. Email: smritidewangan88@gmail.com ORCID: 0000-0002-5429-9883
2Assistant Professor, Department of Applied Science, Faculty of Engineering and Technology, Parul University. Email: prabharawat.modi@gmail.com ORCID: 0000-0001-9082-9792
3Assistant Professor, Department of Chemical Engineering, Vel Tech High Tech Dr. Rangarajan Dr. Sakunthala Engineering College. Email: dineshvishwanathan2210@gmail.com
4Professor of Chemistry, KIIT Deemed to be University, Bhubaneswar.
5Lecturer in Chemistry, Chitalo Degree College, Jajpur (Under Utkal University, Bhubaneswar), Odisha, Pin-755062. Email: pravatdixit@gmail.com ORCID: 0000-000-5984-01117
6M. Pharm Pharmacology, SCHOOL OF PHARMACY, LNCT UNIVERSITY, BHOPAL, (M.P). Email: shivamsachin49@gmail.com
7Department of Physics, MGSM's Dadasaheb Dr. Suresh G. Patil College, Chopda. Email: wagha2541995@gmail.com
immersible polymeric implants have turned out to be a viable approach to sustained and graduated drug delivery, especially to a long-term regimen. The study is aimed at creating and testing biodegradable polymer-based implant systems that are expected to deliver small-molecule drugs and peptide therapeutics in a sustained manner. The main aim was to determine the effects of polymer choice, fabrication methods and drug properties about releasing kinetics, stability and biocompatibility. Solvents based and melt-processing techniques were used to make the implants using established biodegradable polymers, and then methodical drug loading and physicochemical characterisation performed. In vitro release experiments were done to determine release profiles, and the degradation behaviour and biocompatibility were determined using standard analytical and biological assays. The findings showed that the composition and the structure of the implants are crucial factors that can regulate the rate of release, reduce the burst release and retain the integrity of the peptide in the long run.
Keywords: Biodegradable polymers; Polymeric implants; Sustained drug release; Small-molecule drugs; Peptide delivery.
How to cite this article: Dewangan S, Modi P, Dinesh V, Kar B, Dixit PR, Shivam S, Wagh GD. Development Of Biodegradable Polymeric Implants For Sustained Release Of Small-Molecule Or Peptide Drugs. Int J Drug Deliv Technol. 2026; 16(8s): 390-397; DOI: 10.25258/ijddt.16.8s.53
Source of support: Nil.
Conflict of interest: None