1,2*,3,4,5,6,7Department of Pharmaceutics, Netaji Subhas Chandra Bose Institute of Pharmacy, Chakdaha, Nadia, West Bengal, 741222, India
*Corresponding Author: Sudipta Das, Department of Pharmaceutics, Netaji Subhas Chandra Bose Institute of Pharmacy, Chakdaha, Nadia, West Bengal, 741222, India.
This exploration is based on preparation of Ciprofloxacin HCl microspheres with emulsion gelation method. Ciprofloxacin HCl is a well-known first-generation fluoroquinolone antibiotic with versatile usage. Plasma elimination half-life of proposed drug is 4 hours approximately. Controlled release drug delivery system was highly recommendable and successfully achieved for these formulations. Microspheres were generated with polymers like sodium alginate, methyl cellulose, gelatin, magnesium stearate and cross-linked with calcium chloride. Overall, three different combinations of formulations were prepared and evaluated by percentage yield, swelling index, microscopic size analysis, In Vitro drug release study, drug release kinetics, drug entrapment efficiency and stability study. Reports generated from evaluation study represents F3 with highest value of regression coefficient for zero order and Higuchi release kinetics with respective data of 0.941 and 0.981. During In Vitro drug release study F1, F2 and F3 shows 85.024 %, 88.252 % and 89.479 % of drug release after 4 hours study. Ultimately it was found that F3 batch had shown progressive results even after 1 month stability study with less alterations. This particular study had been utilized emulsion gelation method for microsphere preparation and applied magnesium stearate in minimum concentration as release modifier to get controlled release drug delivery system.
Keywords: Ciprofloxacin HCl, Microsphere, Controlled release, Stability Study.
How to cite this article: Roy D, Das S, Majumder S, Pal R, Ghosh S, Sen A, Molla A. Development and evaluation of ciprofloxacin hcl microspheres through emulsion gelation with various combinations of polymers. Int J Drug Deliv Technol. 2026;16(8s): 690-696. DOI: 10.25258/Ijddt.16.8s.76.
Source of support: Nil.
Conflict of interest: None