1Department of Pharmaceutical Medicine, Maharashtra University of Health Sciences, Nashik-422004, Maharashtra, India
2Tara Govt. College (A), Sangareddy, Sangareddy Dt., Telangana, India 502001
3Department of Pharmacology, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research (SRIHER) (DU), Porur, Chennai 600106, India
4Samrat Prthviraj Chauhan College of Pharmacy, Kokhratal, Kashipur, Udham Singh Nagar, Uttarakhand, India
5Pharmacognosy, School of Pharmaceutical Sciences, Shri Guru Ram Rai University, Dehradun, Uttarakhand, India
6Department of Folk Medicine and Pharmacology, Fergana Medical Institute of Public Health, Yangi Turon, Fergana – 150100, Uzbekistan
7Institute of Pharmacy, Pathrikar Campus, Highway No-06, Badnapur, 431202, India
8*Professor, Department of Pharmacognosy, PSG College of Pharmacy, Coimbatore – 641004, India
Email: 1969idacsha@gmail.com
Type 2 diabetes mellitus (T2DM) is a multifactorial metabolic disorder characterized by persistent hyperglycemia, insulin resistance, and progressive pancreatic β-cell dysfunction. Although several synthetic antidiabetic drugs are available, their long-term use is often associated with adverse effects, highlighting the need for safer and multitarget therapeutic alternatives. The present study aimed to design, develop, and pharmacologically evaluate a polyherbal formulation for the management of T2DM. Hydroalcoholic extracts of Azadirachta indica, Gymnema sylvestre, Momordica charantia, and Trigonella foenum-graecum were prepared, optimized, and combined to develop a stable formulation. Physicochemical characterization and phytochemical screening confirmed formulation quality and the presence of bioactive constituents. In vitro evaluation revealed significant, concentration-dependent inhibition of α-amylase and α-glucosidase enzymes, indicating effective control of carbohydrate digestion. The formulation also exhibited strong antioxidant activity in DPPH and ferric reducing antioxidant power (FRAP) assays. Overall, the results suggest that the polyherbal formulation exerts antidiabetic effects through multitarget mechanisms involving enzyme inhibition, antioxidant action, metabolic regulation, and pancreatic protection, supporting its potential as a safe and effective therapeutic approach for T2DM.
Keywords: Polyherbal formulation, Type 2 diabetes mellitus, Antidiabetic activity, Herbal medicine, Pharmacological evaluation.
How to cite this article: Aher VD, Yadavalli V, Nithya S, Negi V, Tailor CS, Umidaxon M, Jaybhaye SS, Christi VEI. Design, Development, and Pharmacological Evaluation of a Polyherbal Formulation for the Management of Type 2 Diabetes Mellitus. Int J Drug Deliv Technol. 2026;16(9s): 38-46; DOI: 10.25258/ijddt.16.9s.5
Source of support: None
Conflict of interest: None