International Journal of

Drug Delivery Technology

ISSN: 0975 4415

Peer Review Journal

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1. Drug Eluting Stent: A promising drug delivery system
Rakesh P.Patel, Samir Patel, Chetan Borkhataria
Drug eluting stent is a topic of current interest in the design of drug delivery systems. Drug-eluting stents deliver potentially high doses of drugs locally for variable time periods in the area of stent implantation, directed at the potential restenosis site. While this is currently achievable, optimal pharmacological therapy is still evolving. Acknowledging the challenge of examining such a dynamic and flourishing field, our goals in this article were to provide a broad perspective of the development of drug-eluting stent technology, to summarize the available clinical data, and to introduce emerging concepts for the understanding and application of this new device in clinical practice.

2. Multiple Unit Asymmetric Membrane Capsule: A Means for Delivery of Highly Water Soluble Drug
Harmeet Singh, Anil K. Philip, Kamla Pathak
A multiple unit, non-disintegrating asymmetric polymeric capsular system was used to deliver highly water-soluble drug in a controlled manner. A highly water-soluble drug, metformin hydrochloride (MHCl), was selected as a model drug to demonstrate how the controlled release could be generated in vitro by changes in the core as well as the coating formulation. Formation of asymmetric capsule wall membrane involved wet phase inversion process, in which the asymmetric membrane (AM) was precipitated on glass mold pins by dipping the mold pins into a coating solution containing the good and bad solvents for the polymer followed by quenching in an aqueous quench bath. The study optimized by 23 factorial design evaluates the influence of coating formulation namely concentration of ethylcellulose and pore former (glycerol) and core component namely controlled release potassium chloride crystals. Scanning Electron Microscopy (SEM) showed the presence of outer dense non porous region and inner, thick, porous region for the prepared AM. Statistical test were applied at P > 0.05 on all the formulations undergoing in vitro release studies. Results showed the solubility of MHCl to have been modulated (reduced) over an extended period of time with pH independent, and osmotic pressure dependant drug release. The release kinetics was found to be zero order.

3. Formulation and Evaluation of Liposomes of Ketoconazole
Rakesh P. Patel , Hardik Patel and Ashok H. Baria
Antifungal drug, Ketoconazole was encapsulated in liposomes for topical application. Ketoconazole liposomes were prepared by thin film hydration technique using soya lecithin, cholesterol and drug in different weight ratios. The prepared liposomes were characterized for size, shape, entrapment efficiency, in-vitro drug release (by franz diffusion cell) and physical stability. The studies demonstrated successful preparation of Ketoconazole liposomes and effect of soya lecithin: cholesterol weight ratio on entrapment efficiency and on drug release.

4. Formulation Development and Characterization of Solid Lipid Nanoparticles Containing Nimesulide
Jain Pushpendra, Mishra Amit , Yadav S.K., Patil U.K. , Baghel U.S. 
The aim of this study was to prepare nimesulide solid lipid nanoparticles (NIM-SLNs), to formulate the controlled drug release and to evaluate its physiochemical characteristics. NIM-SLNs were prepared by an emulsification and low-temperature solidification method. Additionally, attempts have been made to study the effect of individual process parameters stirring speed and stirring time) and formulation parameters (Lecithin concentration, drug concentration and surfactant concentration) on entrapment efficiency. An approximately entrapment efficiency of (60%) and an average drug loading of (1.0%) were achieved from optimized formulation of NIM-SLNs. The results show that the TMZ-SLNs had an average diameter of 187±1.23nm and in vitro drug release was conducted in phosphate-buffered saline (pH 7.4) at 37oC. The cumulative percentages drug release of nimesulide was found approximately 60% in 24 hours and release behavior was in accordance with Higuchi-equation. The results indicate that the SLNs is a promising controlled-release system. It may also allow a reduction in dosage and a decrease in systemic toxicity

5. Magnetized carrier as novel drug delivery system
Jawed Akhtar, Rajeev Chaturvedi, Jyoti Sharma, Deepak Mittal, Pankaj Pardhan 
There has been keen interest in the development of a novel drug delivery system. Novel drug delivery system aims to deliver the drug at a rate directed by the needs of the body during the period of treatment, and target the active entity to the site of action. A number of novel drug delivery systems have emerged encompassing various routes of administration, to achieve controlled and targeted drug delivery, magnetic microcarriers being one of them. These microcarriers include magnetic microspheres, magnetic liposomes, magnetic nanoparticles, magnetic resealed erythrocytes, magnetic emulsion etc. Magnetic micro/nanoparticles & molecular magnetic labels have been used for great number of application in various areas of biosciences, targeted drug delivery, imaging & in bioseparation technology. This review paper will summarize about mechanism of magnetic targeted drug delivery, magnetic carriers ,benefits and drawbacks of magnetic targeting, characterization and application of magnetism in targeted drug delivery and some other field.

6. Development of Solid Lipid Nanoparticles of Lamivudine for Brain Targeting
Pravin Patil, Anil K. Sharma, Subhash C. Dadarwal, Vijay K Sharma 
The objective of present investigation was to enhance brain penetration of Lamivudine, one of the most widely used drugs for the treatment of AIDS. This was achieved through incorporating the drug into solid lipid nanoparticles (SLN) prepared by using emulsion solvent diffusion technique. The formulations were characterized for surface morphology, size and size distribution, percent drug entrapment and drug release. The optimum rotation speed, resulting into better drug entrapment and percent yield, was in the range of 1000-1250 r/min. In vitro cumulative % drug release from optimized SLN formulation was found 40-50 % in PBS (pH-7.4) and SGF (pH-1.2) respectively for 10 h. After 24 h more than 65 % of the drug was released from all formulations in both mediums meeting the requirement for drug delivery for prolong period of time.

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