International Journal of

Drug Delivery Technology

ISSN: 0975 4415

Peer Review Journal

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1. Tulsi Oil Loaded Biocompatible, Stable Organogel with Improved Physical Stability and Prolonged Activity.
Deokar Gitanjali S, Sadgir Priyanka ,Kshirsagar Sanjay J, Kakulte Harshada D, Patil Sushil M

Tulsi oil, though reported to be affective against broad spectrum bacteria and fungi the simple conventional gel formulations could not enter the clinical trials due to instability of Tulsi oil. Microbial growth in the formulation, phase separation and incompatibility with aqueous components are the major concerns associated with formulation and development involving Tulsi oil as the active component. In last few decades several studies have been carried out by Indian scientists and researchers to suggest the role of essential oils and Eugenol in therapeutic potentials of Ocimum sanctum Linn. Eugenol is a phenolic compound and major constituent of essential oils extracted from different parts of Tulsi plant. Various workers have tried extract of Ocimum sanctum against some well known fungal etiological agents as Candida albicans. Candidiasis is a very common disease not only in human but also in animals and therefore always has been a challenge to scientist. Overgrowth of several species including albicans can cause superficial infections such as oropharyngealcandidiasis (thrush) and vulvo vaginal candidiasis (vaginal   candidiasis). Oral candidiasis is common in elderly denture wearers. In otherwise healthy individuals, these infections can be cured with topical or systemic antifungal medications  (commonly over-the-counter antifungal treatments like miconazole or clotrimazole). Ointments, creams, liquid preparations, powders, aerosols, gels are various topical drug delivery systems. A ternary plot depicting proportions of water, Tulsi oil and surfactant mixture with gelator, was prepared to predict the gelling compositions. To figure out the area of ternary plot fulfilling MIC, antifungal susceptibility testing of Tulsi oil was carried out. In- vitro diffusion study was done and percent release was quantified in terms of Eugenol. Further Stability studies were performed. HET- CAM test was carried out to assess biocompatibility. The drug release was found to follow Korsmeyer-peppas model with zero order release pattern which was supported by higher release exponent value, indicating super case II transport systems. The optimized organogel showed shelf life of 54, 42, and 22 days at 40C, 250C, 500C respectively and was found to be biocompatible and physically stable for longer period as compared to conventional Tulsi oil gel formulation. The present study highlights the usefulness of approach selected for study to improve the formulation aspects in terms of physical stability of oily active components.

2. Crosslinked Chitosan/PVA Film, Suturated With 5- Fluorouracil for the Prevention of Proliferative Vitreoretinopathy
Baiyrkhanova A , Ismailova A, Botabekova T, Enin E, Semenova Y
5-Fluorouracil (5-FU)-loaded chitosan (Ch) film for chemotherapy were prepared applying a superhydrophobic surface-based encapsulation technology. The aim of this study was to develop polymeric film with glutaraldehyde (GA) of controlled drug delivery systems for 5 – fluorouracil (FU) as a model drug for the treatment of proliferative vitreoretinopathy. Polymer film of chitosan and polyvinyl alcohol (PVA in 75:25 ratios were prepared and treated with GA. FTIR spectra of 5-FU, Ch/5-FU and Ch/PVA film loaded 5-FU were stud­ied. Physical characteristics such as thickness and swelling coefficient of the film were per­formed. The thermal of the Ch/PVA film was studied with thermogravimethric analysis. The drug loading efficiency, film size and chemical compositions of the film loaded drug were confirmed by UV–vis spectrophotometer and Fourier transform infrared spectroscopy. In vitro release kinetics of drug from the polymeric films was investigated to determine the drug re­lease properties. In vivo study of PVR was showed the efficacy and no toxicity of this formu­lation. Further uses of the film loaded 5 – fluorouracil may provide an efficiency deliverable for ophthalmic administration.



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International Journal of Drug Delivery Technology

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International Journal of Pharmacognosy and Phytochemical Research

International Journal of Current Pharmaceutical Review and Research

International Journal of Toxicological and Pharmacological Research

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