International Journal of

Drug Delivery Technology

ISSN: 0975 4415

Peer Review Journal

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1. Chronotherapeutic Drug Delivery of Ezetimibe Using Press Coating Technology
Singa Neeraja, E Hari Krishna, Shaheen Sultana, Ambedkar P
In the present research work pulsatile drug delivery system of Ezetimibe tablets were formulated by employing compression coating technology. Initially the core tablets were prepared by using various concentrations of super disintegrants, the formulated core tablets were coated with the polymers by using compression coating technology. All the core and press coated tablet formulations were subjected to various evaluation tests. The inner core formulated with ethyl cellulose and outer core with Eudragit L- 100.  Invitro release of Ezetimibe of core tablet formulations F4 was optimized and showed less amount of drug release during lag time. Time dependent pulsatile drug delivery system has been achieved from tablet of formulation F4 which meets demand of chronotherapeutic for drug delivery.

2. Controlled in Vitro Release of Levodopa from Sodium Alginate Membranes
Margarida Franco, Sara Biscaia, Tânia Viana, Nuno Alves, Pedro Morouço
Levodopa (LD) plays a central role in Parkinson’s Disease therapeutics. In this study, we aimed to encapsulate LD in sodium alginate (SA) membranes, and to study its dissolution profiles. Two types of SA membranes, loaded with two different amounts of LD were prepared and compared (M1: 85 mg per 50 ml SA/LD; M2: 127.5 mg per 75 ml SA/LD); membranes production followed a solvent-casting methodology. Calcium chloride was used as a crosslinking agent. LD solubility tests were performed to predict sink conditions required for complete drug dissolution. LD dissolution assays were carried out and UV spectrophotometry was used for cumulative release percentage determination. The obtained data were mathematically evaluated and fitted into mathematical dependent models; the difference factor (f1), the similarity factor (f2) and other parameters like dissolution efficiency (DE) were also used. No differences in the dissolution profiles of both membranes were noticed. Thus, increasing the amount of LD, but keeping the same concentration, led to a similar controlled release. The membranes presented in this work are expected to be a promising contribution in the development of a new controlled drug delivery system for LD administration.

3. A Review on Emerging Floating Drug Delivery System
Christe Sonia Mary M, Sasikumar Swamiappan
Presently, various approaches have been exploited in the prolongation of gastric residence time which includes floating drug delivery system (FDDS), swelling and expanding systems, bio-adhesive systems, modified shape systems and high density systems. Among various methods, floating drug delivery system is considered to be a predominant method. Gastric emptying of dosage forms is an extremely varying process and ability to extend and control the emptying time is a valuable resource for the dosage forms. This FDDS is having the ability to provides a solution for this purpose. The FDDS is a bulk density system lower than the gastric fluid, so that the rest will float on the stomach contents for a prolonged period of time and allowing the drug to release slowly at a desired rate from the system and intensifies the bio-availability of the drug having narrow absorption window. The main intension of writing this review on floating drug delivery system is to study the mechanism of flotation to acheive the gastric retention and to discuss briefly about the background of FDDS, advantages and disadvantages, application of FDDS and factors affecting the gastric retension time.

4. Quantification of Doxycycline Hyclate in Different Pharmaceutical Samples by UV Assay
Kazi Md Mahmudul Hasan, Md Anwarul Haque, Sm Alamgir Kobir, Mobarak Hossain
Objective: Doxycycline hyclate is a broad spectrum antibiotic with activity against a wide range of gram-positive and gram-negative bacteria and it is widely used as a pharmacological agent. A simple, selective, linear, precise and accurate ultraviolet detection (UV) method has been developed and applied for the determination of doxycycline hyclate in different pharmaceutical samples. Methods: Acid-base analysis and titrimetric method were utilized to determine the value of pH and moisture content of purchased pharmaceutical samples. A mixture of methanol and hydrochloric acid (0.01N Methanolic HCl) was used to determine the biochemical properties of doxycycline hyclate. UV detector set at 349 nm was used to monitor the effluent. The purified water was used as solvent. Results: In 1% aqueous solution of doxycycline, three samples (4th, 5th and 7th) showed lower pH values of 1.97, 1.98, and 1.99 respectively.   Furthermore, the same samples indicated the additional moisture contents of 2.81%, 2.85% and 2.83% respectively while considering the acceptance level (1.4% to 2.8%). The method proved to be linear (R2=0.993), precise (RSD=0.79% for inter-day precision), accurate (Recovery=100.59%) and selective regarding possible impurities and excipients of the samples. The doxycycline content obtained in the sample analysis was within the range of 84.05% to 85.80%. Conclusion: The optimized and validated method may be successfully employed to perform routine quality control analyses. Investigation of the pH, moisture content and potency of doxycycline hyclate in different samples give a general view of local pharmacies trade and ensure that the method applied here was validated for this kind of analysis.

5. Evaluation of Formulation Parameters for Development of Aceclofenac Nanosuspension Using Doe Statistical Tool
Sharma Shivkant, Issarani Roshan, Nagori Badri Prakash
The objective of present study was to identify and evaluate formulation variables affecting characteristics of nanosuspension formulations. Full factorial design experimental methodology was used for development of aceclofenac nanosuspension. Formulation factors evaluated were drug to polymer (Polyvinyl alcohol) ratio, amount of surfactant (Sodium dodecyl sulphate) relative to drug and solvent employed for carrying the drug. Total 18 formulations were prepared and their saturation solubility in distilled water and z average particle size were regarded as responses in this study. The response surface methodology utilizing polynomial equation was used to quantify the effect of each formulation variables. All three variables exerted significant effect on particle size and saturation solubility.  Optimized nanosuspensions were obtained using numerical optimization technique by the desirability approach.  The optimum formulation parameters were found to be 400% w/w of drug to polymer ratio and 7.5% w/w of amount of SDS for both solvents. The best optimized formulation obtained from ethanol showed significantly improved saturation solubility 255.39 µg/ml, particle size 477.7 nm and better dissolution efficiency (DE05) 59.77%. The absence of interactions between drug and polymers was confirmed by Fourier transform infrared (FTIR) spectroscopy. The results demonstrated that polyvinyl alcohol was successfully employed for the development of nanosuspension of aceclofenac with higher dissolution efficiency leading to better oral bioavailability.

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