The ultimate goal of any oral drug delivery system is the successful delivery of the drug, in which almost 90% of the drugs are administered to the body for the treatment of various disorders and diseases as it is regarded as the safest, most convenient and most economical method of drug delivery having the highest patient compliance. The aim of the present study is to formulate sustained release matrix tablets of a model drug (Tramadol hydrochloride) using HPMC 100 MCR, HPC and EC 7cps as rate retarding polymers, microcrystalline cellulose as bulking agent, magnesium stearate as lubricant and aerosil as glidant. Drug and polymer interactions were evaluated by using FTIR and DSC. The FTIR spectrum and DSC thermograms stated that drug and polymer are compatible to each other. Tablets were prepared by direct compression technique. The micromeritic properties of formulation mixtures of all the formulations were carried out and they were found to be as angle of repose (31.150
), bulk density (0.310g/ml-0.337g/ml), tapped density (0.355g/ml-0.59g/ml), Carr’s index (8.11%-15.3%), Hausner’s ratio (1.08-1.18) which are within the limits. The formulated tablets were physically acceptable and exhibited acceptable weight variation, friability. In vitro
dissolution studies were carried out using USP type-II dissolution apparatus and of all the formulations F6
(containing HPMC and HPC in equal proportions) exhibited prolonged drug release for about 8 hrsas per the objective of the work. The percent drug content varied between 88% to 99%. It can be concluded from the study that the sustained release tablets can be better alternative over immediate release tablets by improving patient compliance and reducing frequency.