International Journal of

Drug Delivery Technology

ISSN: 0975 4415

Peer Review Journal

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1.Novel formulation development and evaluation of nanoparticles based in situ gelling system for the ophthalmic delivery of Ciprofloxacin hydrochloride
Kranti Pal Singh, Surajpal Verma, Shyam Baboo Prasad, Indu bala
Ciprofloxacin hydrochloride loaded Eudragit RS100 nanoparticles were prepared by using w/o/w emulsification (multiple emulsification) solvent evaporation followed by drying of nanoparticles at 50°C. The nanoparticles were further incorporated into the pH-triggered in situ gel forming system which was prepared using Carbopol 940 in combination with HPMC as viscosifying agent. The developed nanoparticles was evaluated for particle size, zeta potential value and loading efficiency; nanoparticle incorporated in situ gelling system was evaluated for pH, clarity, gelling strength, rheological studies, in-vitro release studies and ex-vivo precorneal permeation studies. The nanopaticle showed the mean particle size varying between 263.5nm – 325.9 nm with the mean zeta potential value of -5.91 mV to -8.13 mV and drug loading capacity varied individually between 72.50% to 98.70% w/w. The formulation was clear with no suspended particles, showed good gelling properties. The gelling was quick and remained for longer time period. The developed formulation was therapeutically efficacious, stable and non-irritant. It provided the sustained release of drug over a period of 8-10 hours.

Abstract Online: 17-October-2015

2. Formulation and Evaluation of Self Nanoemulsifying Drug Delivery System of Nifedipine
Dinesh Kaushik, Jyoti Malik, Satish Sardana
Oral route is the most preferred route of drug administration due to its easy accessibility, intake, and wide range of choices making it economical. Currently, greater than 60% of marketed drugs are oral products. Over 90% of therapeutic compounds given orally areknown to possess oral bioavailability limitations. Therefore, there is a need to explore various approaches that can be used to improve oral drug bioavailability besides using physical and chemical means. The objective of this study is to prepare a formulation i.e. self microemulsifying drug delivery system (SMEDDS) of nifedipine with the intention to improve the increase dissolution rate (solubility). This will ensure the quick absorption and uniform bioavailability of nifedipine. Selection of oils, surfactants and co-surfactants was done by determining % transparency and on the basis of compatibility studies by FTIR spectra analysis. Different SMEDDS formulation were prepared of different ratio of oil:surfactantmix (1:9,2:8,3:7,4:6,5:5,6:4,7:3,8:2,9:1) and different ratio of surfactants : cosurfactants. Pseudo ternary phase diagram were constructed by water titration method to obtain a particle micro-emulsion region (on the basis of clarity and transparency). The formulation B-I was optimized because of maximum transparency (87.35%) and maximum % drug entrapment (95.32%). The average droplet size and zeta potential was found 86.05 and -0.189. The solubility of nifedipine increase in SMEDDS formulation upto72.17%.From in vitro dissolution study it was proved that SMEDDS formulation releases drug at faster rate, thus the objective of increase solubility and hence the better dissolution rate for uniform bioavailability via SMEDDS formulation of nifedipine was successfully achieved.

Abstract Online: 25-November-2015

3. Synthesis  Nanoparticles of Chloroform Fractions of Kaempferia rotunda Rhizome Loaded Chitosan and Biological Activity as Antioxidant
Sri Atun, Retno Arianingrum
The main objectives of this research are to synthesize chitosan nanoparticles  of chloroform fraction of K. rotunda, to characterize these products, and to conduct a biological test on these products as an antioxidant.  Chloroform fraction of K. rotunda was loaded on chitosan nanoparticles and then was prepared by ionic gelation of chitosan with sodium tripolyphosphat (Na-TPP) in various compositions. Characterization of these products were investigated for particle size, zeta potential, and morphology by Scanning Electron Microscophy (SEM). Biological activity of these products as antioxidant were  tested  by the DPPH method. Results of this study showed that nanoparticles can be synthesized at a  concentration of chitosan/ Na-TPP and ratio of 10: 1. The size range of the nanoparticles were between 172 to 877 nm, with a zeta potential of  + 28.06  to + 38.03 mV. The particles were cylinders in shape and had  smooth surfaces. The antioxidant activity of chitosan nanoparticles of chloroform fraction of K. rotunda showed less activity compared with the previous fraction.

Abstract Online: 25-November-2015

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