Development of Solid Lipid Nanoparticles of Lamivudine for Brain Targeting
Pravin Patil1 , Anil K. Sharma2*, Subhash C. Dadarwal2 , Vijay K Sharma3
1 Formulation & Development Laboratory, Indoco Remedies Limited, Mumbai, INDIA 2 School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal M.P., INDIA 3 Krishna Devi Maheshwari Pharmacy College, Bagar, Jhunjhunu, Rajasthan, INDIA
Abstract The objective of present investigation was to enhance brain penetration of Lamivudine, one of the most widely used drugs for the treatment of AIDS. This was achieved through incorporating the drug into solid lipid nanoparticles (SLN) prepared by using emulsion solvent diffusion technique. The formulations were characterized for surface morphology, size and size distribution, percent drug entrapment and drug release. The optimum rotation speed, resulting into better drug entrapment and percent yield, was in the range of 1000-1250 r/min. In vitro cumulative % drug release from optimized SLN formulation was found 40-50 % in PBS (pH-7.4) and SGF (pH-1.2) respectively for 10 h. After 24 h more than 65 % of the drug was released from all formulations in both mediums meeting the requirement for drug delivery for prolong period of time
Keywords: Emulsion solvent diffusion method, Polydispersity index, Blood brain barrier (BBB).Zeta potential.