Formulation and Evaluation of Carbopol Gel Containing Liposomes of Ketoconazole. (Part-II)
Rakesh P. Patel1*, Hardik H. Patel 1 and Ashok H. Baria2
1 Department of Pharmaceutics, S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Kherva, 382711, Mehsana, Gujarat, India. 2 S. J. Thakkar Pharmacy College, Rajkot, Gujrat, India
ABSTRACT The aim of this work was to prepare and evaluate the topical carbopol gel formulation containing ketoconazole encapsulated liposomes. Ketoconazole loaded liposomes were prepared by thin film hydration technique. The prepared liposomes were incorporated into 1% carbopol gel, and the systems were evaluated for in-vitro drug release, drug retention into skin and invitro antifungal activity. The in-vitro permeation of ketoconazole using wistar albino rat skin from liposomal gel was compared with that of plain drug gel and also with plain drug cream containing 2% w/w of ketoconazole. The release of ketoconazole from liposomal gel was much slower than from non liposomal formulations. Gel containing liposomal ketoconazole showed maximum antifungal activity after 30 hours over plain ketoconazole gel and cream formulations.
Keywords: Ketoconazole, Topical gel, Liposomes, Antifungal, In-vitro release study and Drug retention study