International Journal of

Drug Delivery Technology

ISSN: 0975 4415

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Title:

Preparation and Assessment of Rapidly-Dissolving Tablets of Diltiazem HCl By Using Native and Man-Made Super Disintegrants

Author:

Mohan Varma M¹, Mohan Sai², Prasanna E³, Kusumanjali Devi Ch⁴,  Kshema Lathangi M5

Pharmaceutics Department, Shri Vishnu College of Pharmacy, Vishnupur, Bhimavaram, West Godavari (Dist.)534202, Andhra Pradesh, India.

Received: 26th July, 2025; Revised: 25th Aug, 2025; Accepted: 27th Sep, 2025; Available Online: 30th Nov, 2025

 

ABSTRACT

Rapidly dissolving tablets, also known as orally disintegrating tablets (ODTs)   are solid unit dosage forms that disintegrate or dissolve rapidly in the mouth without chewing and water. They offer an advantage particularly for pediatric and geriatric populations who have difficulty in swallowing conventional tablets and capsules. The present study focuses on the formulation and evaluation of Diltiazem HCl rapidly dissolving tablets using both natural and synthetic superdisintegrants, including Sodium Starch Glycolate, Croscarmellose Sodium, Guar Gum, and ground banana flour. Tablets were prepared via dry granulation. The  formulations (F1–F8) were developed and subjected to pre-compression (bulk density, tapped density, angle of repose, Hausner’s ratio) and post-compression (hardness, friability, drug content, water absorption ratio, wetting time, dissolution, and disintegration time) evaluations. All parameters met the acceptable limits prescribed by the Indian Pharmacopoeia (IP). Among all formulations, F2 exhibited the shortest disintegration time of 28 seconds and the highest drug release of 98% within 30 minutes.  The results demonstrate that natural superdisintegrant like ground banana flour can be effectively used in combination with synthetic agents to formulate efficient ODTs of Diltiazem HCl.

Keywords: Herbal nanoemulsion, Urinary Tract Infection, Synergistic antibacterial activity, Vaccinium macrocarpon, Cinnamomum verum, Tribulus terrestris, In-vitro

How to cite this article: Varma MM, Sai M, Prasanna E, Devi KC, Lathangi MK. Preparation and assessment of rapidly dissolving tablets of diltiazem HCl using native and synthetic superdisintegrants. Int J Drug Deliv Technol. 2025;15(4):27–33.

Source of support: Nil.

Conflict of interest: None

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